{"created":"2023-05-15T14:35:53.314260+00:00","id":46177,"links":{},"metadata":{"_buckets":{"deposit":"6f9ab939-b42e-49d2-b185-d845c7c5924c"},"_deposit":{"created_by":1,"id":"46177","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46177"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046177","sets":["1"]},"author_link":["459810","459803","459815","459806","459814","459817","459811","459805","459804","459807","459812","459809","459813","459808","459816"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"379","bibliographicPageStart":"374","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously showed that carbon ion irradiation can inhibit the expression of the anillin (ANLN) gene, which is regulated by the activation of the phosphatidylinositol-3-kinase (PI3K)/Akt signaling path- way associated with metastasis. The purpose of this study is to compare the effects of carbon ion irradia- tion on the PI3K/Akt signaling pathway to those of photon irradiation. Our study showed that carbon ion irradiation of human lung adenocarcinoma cells A549 decreased their invasion more effectively than pho- ton irradiation did. We found that carbon ion irradiation reduced the nuclear localization of ANLN at lower dose, but did not affect its expression. Low-dose carbon ion irradiation also reduced the level of phosphorylated Akt compared to untreated controls, whereas photon irradiation did not. These results sug- gest that carbon ion irradiation effectively suppresses the metastatic potential of A549 cells by suppressing the PI3K/Akt signaling pathway.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1269/jrr.10102","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogata, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"459803","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Teshima, Teruki"}],"nameIdentifiers":[{"nameIdentifier":"459804","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inaoka, Miho"}],"nameIdentifiers":[{"nameIdentifier":"459805","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minami, Kazumasa"}],"nameIdentifiers":[{"nameIdentifier":"459806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tuchiya, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"459807","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isono, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"459808","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"459809","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuura, Nariaki"}],"nameIdentifiers":[{"nameIdentifier":"459810","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"手島 昭樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"稲岡 美穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"皆巳 和賢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土屋 貴裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"五十野 優","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松浦 成昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459817","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Carbon Ion Irradiation Suppresses Metastatic Potential of Human Non-small Cell Lung Cancer A549 Cells through the Phosphatidylinositol-3-Kinase/Akt Signaling Pathway","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Irradiation Suppresses Metastatic Potential of Human Non-small Cell Lung Cancer A549 Cells through the Phosphatidylinositol-3-Kinase/Akt Signaling Pathway"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-10-07"},"publish_date":"2011-10-07","publish_status":"0","recid":"46177","relation_version_is_last":true,"title":["Carbon Ion Irradiation Suppresses Metastatic Potential of Human Non-small Cell Lung Cancer A549 Cells through the Phosphatidylinositol-3-Kinase/Akt Signaling Pathway"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:54:56.757716+00:00"}