{"created":"2023-05-15T14:35:52.660360+00:00","id":46162,"links":{},"metadata":{"_buckets":{"deposit":"b8d45f60-4745-4938-8948-cc5be87a427e"},"_deposit":{"created_by":1,"id":"46162","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46162"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046162","sets":["1"]},"author_link":["459627","459630","459632","459628","459633","459623","459625","459620","459622","459626","459629","459621","459631","459624"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"277","bibliographicPageStart":"270","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There is a great deal of evidence that a cyclic cascade of inflammatory cytokines, together with the activation of macrophages, is initiated very early after irradiation to develop lung fibrosis in a late phase. To understand the persistent effects of cytokines, the cytokine gene of knock out or transgenic mouse is one of the useful tools. In this study, we evaluated a role of a key molecule, interleukin-6 (IL-6), in the late-phase inflammatory response and subsequent fibrotic changes after irradiation using wild-type (WT) and IL-6 knock out (IL-6 KO) mice. The mice underwent thoracic irradiation with 10 Gy of C-ion beam or sham-irradiation and were examined by histology. Immunoreactivity for IL-6 was induced at the site of bronchiolar epithelium, in pneumocytes and in monocytes by C-ion irradiation. At 24 weeks after irradiation, the infiltration of macrophages, detected by positive immunohistological staining with Mac3 antibody, was observed in alveolar spaces both in WT and IL-6 KO mice. The thickening of bronchiolar and alveolar walls exhibited in WT mice, but not KO mice, and fibrotic changes detected by Masson-Trichrome staining, were observed only in the lungs of WT mice, while it was attenuated in IL-6 KO mice. These results indicated that IL-6 might not be essential for activating macrophages in the late phase, but plays an important role for fibrotic changes of the alveolar wall after irradiation.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Saito-Fujita, Tomoko"}],"nameIdentifiers":[{"nameIdentifier":"459620","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"459621","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Etsuko"}],"nameIdentifiers":[{"nameIdentifier":"459622","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakawatari, Miyako"}],"nameIdentifiers":[{"nameIdentifier":"459623","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujita, Hidetoshi"}],"nameIdentifiers":[{"nameIdentifier":"459624","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moritake, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"459625","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"459626","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 知子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459627","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459628","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 悦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤田 英俊","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"盛武 敬","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459633","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Attenuated Lung Fibrosis in Interleukin 6 Knock-out Mice after C-ion Irradiation to Lung","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Attenuated Lung Fibrosis in Interleukin 6 Knock-out Mice after C-ion Irradiation to Lung"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-08-17"},"publish_date":"2011-08-17","publish_status":"0","recid":"46162","relation_version_is_last":true,"title":["Attenuated Lung Fibrosis in Interleukin 6 Knock-out Mice after C-ion Irradiation to Lung"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:07.382535+00:00"}