{"created":"2023-05-15T14:35:52.222890+00:00","id":46152,"links":{},"metadata":{"_buckets":{"deposit":"16d9d48f-5f34-4f09-8a9b-97ab42324e14"},"_deposit":{"created_by":1,"id":"46152","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46152"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046152","sets":["1"]},"author_link":["459515","459516","459517","459518"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"728","bibliographicPageStart":"715","bibliographicVolumeNumber":"85","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Radiotherapy using charged and/or high-linear energy transfer (LET) particles has a long history, starting with proton beams up to now carbon-ions. Radiation quality of particle beams is different from conventional photons, and\ntherefore the biological effects of high-LET irradiation have attracted scientific interests of many scientists in basic and clinical fields. A brief history of particle radiotherapy in the past half-century is followed by the reviewed biological effectiveness of high-LET charged particles.\nResults: The latter includes 54 papers presenting 506 RBE (relative biological effectiveness) values for carbon ions and a total of 290 RBE values for other ions identified from 48 papers. By setting a selection window of LET up to 100 keV/mm, we\nfitted a linear regression line to an LET-RBE relation. The resulting slope of the regression line had a dimension of mm/keV, and showed different steepness for different cells/tissues and endpoints as well. The steepest regression was found for\nchromosome aberration of human malignant melanoma while the shallowest was for apoptosis of rodent cells/tissue. Both tumour and normal tissue showed relatively shallower slopes than colony formation.\nConclusions: In general, there is a large variation of slope values, but the majority (25 out of 29 values) of data was smaller than 0.05 mm/keV.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"459515","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kase, Yuuki"}],"nameIdentifiers":[{"nameIdentifier":"459516","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459517","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加瀬 優紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459518","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Biological characteristics of carbon-ion therapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Biological characteristics of carbon-ion therapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-26"},"publish_date":"2011-07-26","publish_status":"0","recid":"46152","relation_version_is_last":true,"title":["Biological characteristics of carbon-ion therapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:14.903752+00:00"}