{"created":"2023-05-15T14:35:52.093934+00:00","id":46149,"links":{},"metadata":{"_buckets":{"deposit":"d37ee2b8-972f-4c50-a2e9-76e64af2caa1"},"_deposit":{"created_by":1,"id":"46149","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46149"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046149","sets":["1"]},"author_link":["459486","459491","459484","459479","459481","459485","459489","459488","459487","459490","459483","459480","459482"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1328","bibliographicPageStart":"1322","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"Journal of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, we developed [methyl-11C]4'-thiothymidine (11C-4DST) as an in vivo cell proliferation marker. The present study was performed to determine the safety, distribution, radiation dosimetry, and initial brain tumor imaging of 11C-4DST in humans. Methods: Multiorgan biodistribution and radiation dosimetry of 11C-4DST were assessed in 3 healthy humans, who underwent 2-h whole-body PET scanning. Radiation dosimetry was estimated from the residence times of source organs using the OLINDA program. Six brain tumor patients underwent dynamic 11C-4DST scans with arterial blood sampling. These patients were also evaluated with 11C-methionine PET on the same day (n = 4) as, or 3 wk before (n = 2), 11C-4DST PET studies. Metabolites in plasma and urine samples were analyzed by high-performance liquid chromatography. Breakdown of the blood–brain barrier in tumor tissue was confirmed by gadolinium-enhanced T1-weighted MRI. Results: There were no serious adverse events in any subjects at any time during the study period. 11C-4DST PET demonstrated selective uptake in the bone marrow, which has a high rate of proliferation. In addition, high-level uptake was also seen in the liver. The highest absorbed organ dose was in the urinary bladder wall (17.6 muGy/MBq). The estimated effective dose for 11C-4DST was 4.2 muSv/MBq. 11C-4DST showed little uptake in normal brain tissues, resulting in low background activity for imaging of brain tumors. In contrast, 11C-4DST PET demonstrated rapid uptake in aggressive tumor masses, whereas no signal of 11C-4DST was seen in clinically stable disease in which 11C-methionine uptake was high. The distribution pattern of 11C-methionine in tumor regions was not always identical to that of 11C-4DST. Analysis of plasma samples by high-performance liquid chromatography indicated that more than 60% of the radioactivity was present as unchanged 11C-4DST at 20 min. Conclusion: The initial findings of the present study in a small group of patients indicated that 11C-4DST PET is feasible for imaging of brain tumors. Dosimetry and pharmacologic safety were acceptable at the dose required for adequate PET images.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0161-5505","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Toyohara, Jun"}],"nameIdentifiers":[{"nameIdentifier":"459479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nariai, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"459480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"459481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"459482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"459483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Irie, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"459484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"459485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"459486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"459487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"豊原 潤","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"成相 直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459491","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Whole-Body Distribution and Brain Tumor Imaging with 11C-4DST: a Pilot Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Whole-Body Distribution and Brain Tumor Imaging with 11C-4DST: a Pilot Study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-25"},"publish_date":"2011-07-25","publish_status":"0","recid":"46149","relation_version_is_last":true,"title":["Whole-Body Distribution and Brain Tumor Imaging with 11C-4DST: a Pilot Study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:16.963201+00:00"}