{"created":"2023-05-15T14:35:52.007211+00:00","id":46147,"links":{},"metadata":{"_buckets":{"deposit":"05e18249-4116-45b1-8bbc-b3656d066198"},"_deposit":{"created_by":1,"id":"46147","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46147"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046147","sets":["1"]},"author_link":["459454","459447","459450","459458","459448","459445","459456","459451","459446","459453","459457","459444","459455","459459","459440","459452","459442","459441","459443","459449","459461","459460"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1370","bibliographicPageStart":"1362","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Stem Cells"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"c-Myc transduction has been considered previously to be non-essential for induced pluripotent stem cell (iPSC) generation. In our current study, we investigated the effects of c-Myc transduction on the generation of iPSCs from an inbred strain using a genome integration-free vector to exclude the effects of the genetic background and the genomic integration of exogenous genes. Our findings reveal a clear difference between iPSCs generated using the four defined factors including c-Myc (4F-iPSCs) and those produced withot c-Myc (3F-iPSCs). Molecular and cellular analyses did not reveal any differences between 3F- and 4F-iPSCs, as reported previously. However, a chimeric mice formation test indicated clear differences whereby few highly chimeric mice and no germline transmission was observed using 3F-iPSCs. Similar differences were also observed in the mouse line that has been widely used in iPSC studies. Furthermore, the defect in 3F-iPSCs was considerably improved by trichostatin A, a HDAC inhibitor, indicating that c-Myc plays a crucial role in iPSC generation through the control of histone acetylation. Indeed, low levels of histone acetylation were observed in 3F-iPSCs. Our results shed new light on iPSC generation mechanisms and strongly recommend c-Myc transduction for preparing high quality iPSCs.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/stem.685","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1066-5099","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Araki, Ryoko"}],"nameIdentifiers":[{"nameIdentifier":"459440","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimori, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"459441","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uda, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"459442","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Miki"}],"nameIdentifiers":[{"nameIdentifier":"459443","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jincho, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"459444","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tamura, Chihiro"}],"nameIdentifiers":[{"nameIdentifier":"459445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sunayama, Misato"}],"nameIdentifiers":[{"nameIdentifier":"459446","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Syunsuke"}],"nameIdentifiers":[{"nameIdentifier":"459447","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"459448","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"A, Yoshida Mitsuaki"}],"nameIdentifiers":[{"nameIdentifier":"459449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasama, Yasuji"}],"nameIdentifiers":[{"nameIdentifier":"459450","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Masumi"}],"nameIdentifiers":[{"nameIdentifier":"459451","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒木 良子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459452","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 ゆう子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459453","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇田 昌広","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459454","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中村 美樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459455","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神長 祐子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459456","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"砂山 美里","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459457","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 俊輔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459458","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"杉浦 真由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠間 康次","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459460","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安倍 真澄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459461","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Crucial Role of c-Myc in the Generation of Induced Pluripotent Stem Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Crucial Role of c-Myc in the Generation of Induced Pluripotent Stem Cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-19"},"publish_date":"2011-07-19","publish_status":"0","recid":"46147","relation_version_is_last":true,"title":["Crucial Role of c-Myc in the Generation of Induced Pluripotent Stem Cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:18.401024+00:00"}