{"created":"2023-05-15T14:35:51.570919+00:00","id":46137,"links":{},"metadata":{"_buckets":{"deposit":"5e75abd1-0790-4835-896c-04d515292fcd"},"_deposit":{"created_by":1,"id":"46137","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46137"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046137","sets":["1"]},"author_link":["459341","459340","459343","459348","459347","459342","459344","459346","459345"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"195","bibliographicPageStart":"188","bibliographicVolumeNumber":"79","bibliographic_titles":[{"bibliographic_title":"Journal of Reproductive Immunology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Antiphospholipid antibody (aPL) is associated with thromboembolism. There is scant evidence of a relationship between the aPL profile and serious adverse pregnancy outcome. The aim of this study was to assess whether aPL measurements during early pregnancy were useful in predicting a serious adverse pregnancy outcome. In this prospective study, we measured aPLs, including lupus anticoagulant (LA), IgG, IgM, IgA anticardiolipin antibody (aCL), IgG, IgM phosphatidylserine-dependent antiprothrombin antibody, and IgG kininogen-dependent antiphosphatidylethanolamine antibody (aPE) during the first trimester in a consecutive series of 1155 women. The 99 th percentile cut-off values in each aPL were determined using samples from 105 women who did not exhibit any pregnancy morbidity. We assessed the predictive risk of a serious adverse pregnancy outcome adjusted for confounding factors. We found that IgG aCL was associated with developing pregnancy-induced hypertension (PIH) (odds ratio 11.4, 95% CI 2.7-48); IgG aPE with PIH (8.3, 2.4-29), severe PIH (20.4, 4.5-91), and premature delivery (PD) (12.7, 3.1-50); and LA with PD (11.0, 2.8-44) and low birth weight (8.0, 2.1-31). The combinations of IgG aPE plus IgG aCL (17.5, 4.7-66.7) or IgG aPE plus LA (22.2, 5.4-909) measurements predicted severe PIH with 30.8% sensitivity and 99.2% specificity. We conclude that aPL measurements during early pregnancy may be useful in predicting adverse pregnancy outcome.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0165-0378","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamada, Hideto"}],"nameIdentifiers":[{"nameIdentifier":"459340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsumi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"459341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobashi, Gen"}],"nameIdentifiers":[{"nameIdentifier":"459342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohta, Kaori"}],"nameIdentifiers":[{"nameIdentifier":"459343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Takao"}],"nameIdentifiers":[{"nameIdentifier":"459344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minakami, Hisanori"}],"nameIdentifiers":[{"nameIdentifier":"459345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"459346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小橋 元","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田 薫里","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459348","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension and adverse pregnancy outcomes.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension and adverse pregnancy outcomes."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-14"},"publish_date":"2011-07-14","publish_status":"0","recid":"46137","relation_version_is_last":true,"title":["Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension and adverse pregnancy outcomes."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:25.491884+00:00"}