{"created":"2023-05-15T14:35:51.096038+00:00","id":46126,"links":{},"metadata":{"_buckets":{"deposit":"36146583-2f2e-44dd-ae76-805c6da660d0"},"_deposit":{"created_by":1,"id":"46126","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46126"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046126","sets":["1"]},"author_link":["459234","459232","459227","459226","459235","459237","459231","459247","459229","459244","459236","459245","459238","459242","459243","459240","459230","459241","459239","459233","459246","459228"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2033","bibliographicPageStart":"2023","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Stem Cells"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Therapeutic cloning, whereby nuclear transfer (NT) is used to generate embryonic stem cells (ESCs) from blastocysts, has been demonstrated successfully in mice and cattle. However, if NT-ESCs have abnormalities, such as those associated with the offspring produced by reproductive cloning, their scientific and medical utilities might prove limited. To evaluate the characteristics of NT-ESCs, we established more than 150 NT-ESC lines from adult somatic cells of several mouse strains. Here, we show that these NT-ESCs were able to differentiate into all functional embryonic tissues in vivo. Moreover, they were identical to blastocyst-derived ESCs in terms of their expression of pluripotency markers in the presence of tissue-dependent differentially DNA methylated regions, in DNA microarray profiles, and in high-coverage gene expression profiling. Importantly, the NT procedure did not cause irreversible damage to the nuclei. These similarities of NT-ESCs and ESCs indicate that murine therapeutic cloning by somatic cell NT can provide a reliable model for preclinical stem cell research.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1634/stemcells.2005-0537","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1066-5099","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakayama, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"459226","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"L, Jakt Martin"}],"nameIdentifiers":[{"nameIdentifier":"459227","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masako"}],"nameIdentifiers":[{"nameIdentifier":"459228","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Araki, Ryoko"}],"nameIdentifiers":[{"nameIdentifier":"459229","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hikichi, Takafusa"}],"nameIdentifiers":[{"nameIdentifier":"459230","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishigami, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"459231","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohta, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"459232","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Van, Thuan Nguyen"}],"nameIdentifiers":[{"nameIdentifier":"459233","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mizutani, Eiji"}],"nameIdentifiers":[{"nameIdentifier":"459234","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakaide, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"459235","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Senda, Sho"}],"nameIdentifiers":[{"nameIdentifier":"459236","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"459237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Mitsuhiro"}],"nameIdentifiers":[{"nameIdentifier":"459238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyake, Masashi"}],"nameIdentifiers":[{"nameIdentifier":"459239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Masumi"}],"nameIdentifiers":[{"nameIdentifier":"459240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishikawa, Shinichi"}],"nameIdentifiers":[{"nameIdentifier":"459241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shiota, Kunio"}],"nameIdentifiers":[{"nameIdentifier":"459242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakayama, Teruhiko"}],"nameIdentifiers":[{"nameIdentifier":"459243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒木 良子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安倍 真澄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西川 伸一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459246","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若山 照彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"459247","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Equivalency of nuclear transfer-derived embryonic stem cells to those derived from fertilized mouse blastocysts.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Equivalency of nuclear transfer-derived embryonic stem cells to those derived from fertilized mouse blastocysts."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-07-14"},"publish_date":"2011-07-14","publish_status":"0","recid":"46126","relation_version_is_last":true,"title":["Equivalency of nuclear transfer-derived embryonic stem cells to those derived from fertilized mouse blastocysts."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:55:33.172013+00:00"}