@article{oai:repo.qst.go.jp:00046115,
 author = {Jincho, Yuko and Araki, Ryoko and Fujimori, Yuko and Tamura, Chihiro and Nakamura, Miki and Ando, Syunsuke and Kasama, Yasuji and Abe, Masumi and 神長 祐子 and 荒木 良子 and 藤森 ゆう子 and 中村 美樹 and 安藤 俊輔 and 笠間 康次 and 安倍 真澄},
 issue = {34},
 journal = {The Journal of Biological Chemistry},
 month = {Aug},
 note = {Although the induction of genome integration-free induced pluripotent stem cells (iPSCs) has been reported, c-Myc was still required for the efficient generation of these cells. Herein, we report mouse strain-dependent differences in the c-Myc dependence for iPSC generation and the successful generation of genome integration-free iPSCs without c-Myc transduction using C57BL/6 mouse embryonic fibroblasts. We performed 49 independent experiments and obtained a total of 24 iPSC clones, including 18 genome integration-free iPSC clones. These iPSCs were indistinguishable from embryonic stem cells and from iPSCs generated using other methods. Furthermore, the generation of three-factor iPSCs free of virus vectors revealed the contribution of c-Myc to the genomic integration of external genes. C57BL/6 is an inbred mouse strain with substantial advantages for use in genetic and molecular biological studies due to its use in the whole mouse genome sequencing project. Thus, the present series of C57BL/6 iPSCs generated by various procedures will serve as a valuable resource for future genetic studies of iPSC generation.},
 pages = {26384--26389},
 title = {Generation of Genome Integration-free Induced Pluripotent Stem Cells from Fibroblasts of C57BL/6 Mice without c-Myc Transduction},
 volume = {285},
 year = {2010}
}