{"created":"2023-05-15T14:35:49.495998+00:00","id":46089,"links":{},"metadata":{"_buckets":{"deposit":"91b81379-b8bb-48e4-8add-43515d21a897"},"_deposit":{"created_by":1,"id":"46089","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46089"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046089","sets":["1"]},"author_link":["458822","458825","458816","458826","458827","458821","458828","458832","458817","458819","458818","458815","458820","458830","458829","458823","458831","458824"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"191","bibliographicPageStart":"187","bibliographicVolumeNumber":"495","bibliographic_titles":[{"bibliographic_title":"Neuroscience Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oseltamivir phosphate (Tamiflu®) is an orally active anti-influenza drug, which is hydrolyzed to its\nmetabolite Ro 64-0802 inhibiting the influenza virus with potent activity. The abnormal behavior of\nyoung influenza patients associated with the use of oseltamivir has developed to a social problem in\ncountries where Tamiflu is often prescribed. It is important to determine the amount of oseltamivir in\nthe brain and to elucidate the relationship between its presence and neuropsychiatric side effects. The\naim of this study was to determine the radioactivity in the infant, juvenile and adult rat brains after injection\nof [11C]oseltamivir into the rats using PET and autoradiography. After injection of this radioligand,\nthe highest radioactivity was found in the infant brain and the radioactivity level decreased with age.\nEx vivo autoradiography on the infant brain displayed a relatively higher radioactivity in the cerebellum\nthan that in the cerebrum. Pretreatment with cyclosporin A (an inhibitor for P-glycoprotein) increased\nthe brain radioactivity. These results give helpful insights into elucidating why the neuropsychiatric side\neffects of oseltamivir occur in young patients.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0304-3940","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hatori, Akiko"}],"nameIdentifiers":[{"nameIdentifier":"458815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yui, Joji"}],"nameIdentifiers":[{"nameIdentifier":"458816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yanamoto, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"458817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamasaki, Tomoteru"}],"nameIdentifiers":[{"nameIdentifier":"458818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"458819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takei, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"458820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arai, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"458821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"458822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"458823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽鳥 晶子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"由井 譲二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柳本 和彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山崎 友照","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河村 和紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武井 誠","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒井 拓也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福村 利光","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"張 明栄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458832","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Determination of radioactivity in infant, juvenile and adult rat brains after injection of anti-influenza drug [11C]oseltamivir using PET and autoradiography","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Determination of radioactivity in infant, juvenile and adult rat brains after injection of anti-influenza drug [11C]oseltamivir using PET and autoradiography"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-06-02"},"publish_date":"2011-06-02","publish_status":"0","recid":"46089","relation_version_is_last":true,"title":["Determination of radioactivity in infant, juvenile and adult rat brains after injection of anti-influenza drug [11C]oseltamivir using PET and autoradiography"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:56:00.017477+00:00"}