@article{oai:repo.qst.go.jp:00046089,
 author = {Hatori, Akiko and Yui, Joji and Yanamoto, Kazuhiko and Yamasaki, Tomoteru and Kawamura, Kazunori and Takei, Makoto and Arai, Takuya and Fukumura, Toshimitsu and Zhang, Ming-Rong and 羽鳥 晶子 and 由井 譲二 and 柳本 和彦 and 山崎 友照 and 河村 和紀 and 武井 誠 and 荒井 拓也 and 福村 利光 and 張 明栄},
 issue = {3},
 journal = {Neuroscience Letters},
 month = {May},
 note = {Oseltamivir phosphate (Tamiflu®) is an orally active anti-influenza drug, which is hydrolyzed to its
metabolite Ro 64-0802 inhibiting the influenza virus with potent activity. The abnormal behavior of
young influenza patients associated with the use of oseltamivir has developed to a social problem in
countries where Tamiflu is often prescribed. It is important to determine the amount of oseltamivir in
the brain and to elucidate the relationship between its presence and neuropsychiatric side effects. The
aim of this study was to determine the radioactivity in the infant, juvenile and adult rat brains after injection
of [11C]oseltamivir into the rats using PET and autoradiography. After injection of this radioligand,
the highest radioactivity was found in the infant brain and the radioactivity level decreased with age.
Ex vivo autoradiography on the infant brain displayed a relatively higher radioactivity in the cerebellum
than that in the cerebrum. Pretreatment with cyclosporin A (an inhibitor for P-glycoprotein) increased
the brain radioactivity. These results give helpful insights into elucidating why the neuropsychiatric side
effects of oseltamivir occur in young patients.},
 pages = {187--191},
 title = {Determination of radioactivity in infant, juvenile and adult rat brains after injection of anti-influenza drug [11C]oseltamivir using PET and autoradiography},
 volume = {495},
 year = {2011}
}