@article{oai:repo.qst.go.jp:00046079,
 author = {Suto, Yumiko and Akiyma, Miho and Yamada, Yuji and 數藤 由美子 and 穐山 美穂 and 山田 裕司},
 issue = {1},
 journal = {Cytologia : International Journal of Cytology},
 month = {Mar},
 note = {Multicentric chromosomes, as represented by dicentric chromosomes, are
considered to be sensitive and specific biomarkers for assessing radiation
dose.  Efforts have been made to precisely localize centromeres by
fluorescence in situ hybridization (FISH) using pan-centromeric peptide
nucleic acid (PNA) probes, which bind to the target centromeric DNA
sequences quickly.  We analyzed radiation-induced chromosomal aberrations by
our modified technique that is simpler than the standard PNA - FISH
protocol.  Under our experimental conditions, the detection efficiency of
centromeric signals was 100%, while that of telomeric signals was 90-100%.},
 pages = {1--2},
 title = {Unequivocal detection of radiation-induced multicentric chromosomes by fluorescence in situ hybridization using peptide nucleic acid probes},
 volume = {76},
 year = {2011}
}