@article{oai:repo.qst.go.jp:00046046,
 author = {Kato, Koichi and Tsuji, Atsushi and Saga, Tsuneo and Zhang, Ming-Rong and 加藤 孝一 and 辻 厚至 and 佐賀 恒夫 and 張 明栄},
 issue = {8},
 journal = {Bioorganic & Medicinal Chemistry Letters},
 month = {Apr},
 note = {We describe the synthesis of 11C-labeled a-aminoisobutyric acid 2 from iodo[11C]methane and methyl N-(diphenylmethylen)-D,L-alaniate (5). The tetrabutylammonium fluoride (TBAF)-promoted a-[11C]methylation of sterically hindered analog 5 was a key step in our synthesis process. Total radiochemical conversion of 2 was high and a remote-controlled synthesis was carried out. A comparative tumor positron emission tomography (PET) imaging study using the same model mouse showed higher uptake of 2 than with 11C-labeled methionine and [18F] fluorodeoxyglucose (FDG).},
 pages = {2437--2440},
 title = {An efficient and expedient method for the synthesis of 11C-labeled a-aminoisobutyric acid: A tumor imaging agent potentially useful for cancer diagnosis},
 volume = {21},
 year = {2011}
}