{"created":"2023-05-15T14:35:46.944946+00:00","id":46031,"links":{},"metadata":{"_buckets":{"deposit":"bcca28eb-03d9-40b7-a549-4b35a03e464d"},"_deposit":{"created_by":1,"id":"46031","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46031"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046031","sets":["1"]},"author_link":["458115","458116","458119","458125","458120","458118","458126","458124","458127","458123","458117","458121","458122","458128"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2146","bibliographicPageStart":"2138","bibliographicVolumeNumber":"128","bibliographic_titles":[{"bibliographic_title":"International Journal of Cancer"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Malignant mesothelioma (MM) is a fatal malignancy with a rapidly increasing incidence in industrialized countries because of the widespread use of asbestos in the past centuries. Early diagnosis of MM is critical for a better prognosis, but this is often difficult because of the lack of disease-specific diagnostic imaging. Here we report that manganese-enhanced magnetic resonance imaging (MEMRI) represents a promising approach for a more selective mesothelioma imaging by monitoring a high-level expression of manganese-superoxide dismutase (Mn-SOD), which is observed in many MM. We found that most human MM cells over-expressed Mn-SOD protein compared to human mesothelial cells, and that NCI-H226 human MM cells highly expressed Mn-SOD and augmented Mn accumulation when loaded with manganese chloride (MnCl(2)). The cells showed marked T(1)-signal enhancement on in vitro MRI after incubation with MnCl(2) because of the T(1) shortening effect of Mn(2+). H226 subcutaneous tumor was preferentially enhanced compared to a lung adenocarcinoma cell tumor and another human MM cell tumor in MnCl(2)-enhanced T(1)-weighted MR image (T(1)WI), correlating with their respective Mn-SOD expression levels. Moreover, in a more clinically relevant setting, H226 xenografted pleural tumor was markedly enhanced and readily detected by MEMRI using manganese dipyridoxyl diphosphate (MnDPDP), a clinically used contrast agent, as well as MnCl(2). Therefore, we propose that MEMRI can be a potentially powerful method for non-invasive detection of MM, with high spatial resolution and marked signal enhancement, by targeting Mn-SOD.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/ijc.25547","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0020-7136","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasegawa, Sumitaka"}],"nameIdentifiers":[{"nameIdentifier":"458115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koshikawa, Michiko"}],"nameIdentifiers":[{"nameIdentifier":"458116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Shigeyoshi"}],"nameIdentifiers":[{"nameIdentifier":"458117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morokoshi, Yukie"}],"nameIdentifiers":[{"nameIdentifier":"458118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"458119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"458120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"458121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 純崇","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"越川 道子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 茂芳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"諸越 幸恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458126","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458127","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"458128","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-04-12"},"publish_date":"2011-04-12","publish_status":"0","recid":"46031","relation_version_is_last":true,"title":["Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:56:41.179188+00:00"}