@article{oai:repo.qst.go.jp:00045994,
 author = {Shimazaki, Jun and Tsuji, Hiroshi and Ishikawa, Hitoshi and Okada, Tohru and Akakura, Kouichirou and Harada, Masaoki and Tsujii, Hirohiko and et.al and 島崎 淳 and 辻 比呂志 and 石川 仁 and 岡田 徹 and 赤倉 功一郎 and 原田 昌興 and 辻井 博彦},
 issue = {12},
 journal = {Anticancer Research},
 month = {Dec},
 note = {Abstract
BACKGROUND/AIM: Carbon ion radiotherapy is expected to be suitable to treat localized prostate cancer because it yields great biological and physical effects. The aim of this study was to examine long-term results and subsequent outcomes after biochemical failure.
PATIENTS AND METHODS: A total of 254 patients were treated from the beginning of 2003 and followed through 2009. Long-term hormone therapy was also used for some intermediate-risk and high-risk patients.
RESULTS: Among the patients examined, 54 patients experienced biochemical failure. Failure-free survival was 76%, 91% and 76% at eight years in low-risk, intermediate-risk and high-risk patients, respectively. Clinical progression occurred only in high-risk patients, with 89% progression-free survival at eight years. After biochemical failure, diseases of most patients were well controlled by salvage therapy but twelve high-risk patients (5%) died of prostate cancer.
CONCLUSION: Carbon ion radiotherapy had an excellent effect on localized prostate cancer. Factors influencing salvage therapy included PSA kinetics and duration between radiation and failure.},
 pages = {5105--5111},
 title = {Carbon ion radiotherapy for treatment of prostate cancer and subsequent outcomes after biochemical failure},
 volume = {30},
 year = {2010}
}