@article{oai:repo.qst.go.jp:00045991,
 author = {Hirobe, Tomohisa and Ito, Shosuke and Wakamatsu, Kazumasa and 廣部 知久},
 issue = {1},
 journal = {Pigment Cell & Melanoma Research},
 month = {Sep},
 note = {The mouse pink-eyed dilution (p) locus is known to control eumelanin synthesis, melanosome morphology, and tyrosinase activity in melanocytes. However, it is not well elucidated whether the mutant allele, p affects pheomelanin synthesis. Effects of the p allele on eumelanin and phemelanin synthesis was investigated by chemical analysis of dorsal hairs of 5-week-old mice obtained from the F2 generations (black, pink-eyed black, recessive yellow, pink-eyed recessive yellow, agouti, and pink-eyed agouti) between C57BL/10JHir (B10)-congenic pink-eyed black mice (B10-p/p) and recessive yellow (B10-Mc1re/Mc1re) or agouti (B10-A/A) mice. The eumelanin content was dramatically (> 20-fold) decreased in pink-eyed black and pink-eyed agouti mice, whereas the pheomelanin content did not decrease in pink-eyed black, pink-eyed recessive yellow and pink-eyed agouti mice compared to the corresponding P/P mice. These results suggest that the pink-eyed dilution allele greatly inhibits eumelanin synthesis, but not pheomelanin synthesis.},
 pages = {241--246},
 title = {The mouse pink-eyed dilution allele of the P-gene greatly inhibits eumelanin but not pheomelanin synthesis},
 volume = {24},
 year = {2010}
}