@article{oai:repo.qst.go.jp:00045970,
 author = {Yui, Joji and Hatori, Akiko and Kawamura, Kazunori and Yamasaki, Tomoteru and Yanamoto, Kazuhiko and Yoshida, Yuichiro and Ogawa, Masanao and Kumata, Katsushi and Fujinaga, Masayuki and Nengaki, Nobuki and Fukumura, Toshimitsu and Suzuki, Kazutoshi and Zhang, Ming-Rong and 由井 譲二 and 羽鳥 晶子 and 河村 和紀 and 山崎 友照 and 柳本 和彦 and 吉田 勇一郎 and 小川 政直 and 熊田 勝志 and 藤永 雅之 and 念垣 信樹 and 福村 利光 and 鈴木 和年 and 張 明栄},
 issue = {1},
 journal = {NeuroImage},
 month = {Jan},
 note = {The aim of this study was to visualize early infarction in the rat brain after ischemia using a translocator protein (TSPO) (18 kDa) PET ligand [11C]DAC with ultra-high specific activity (SA) of 3670–4450 GBq/mumol.
An infarction model of rat brain was prepared by ischemic surgery and evaluated 2 days after ischemia using small-animal PET and in vitro autoradiography. Early infarction with a small increase of TSPO expression in the brain was visualized using PET with high SA [11C]DAC (average 4060 GBq/mumol), but was not distinguished clearly with usually reported SA [11C]DAC (37 GBq/mumol). Infarction in the rat brain 4 days after ischemia was visualized using high and usually reported SAs [11C]DAC. Displacement experiments with unlabeled TSPO-selective AC-5216 or PK11195 diminished the difference in radioactivity between ipsilateral and contralateral sides, confirming that the increased uptake on the infracted brain was specific to TSPO. In vitro autoradiography with high SA [11C]DAC showed that the TSPO expression increased on early infarction in the rat brain. High SA [11C]DAC is a useful and sensitive biomarker for the visualization of early infarction and the characterization of TSPO expression which was slightly elevated in the infarcted brain using PET.},
 pages = {123--130},
 title = {Visualization of early infarction in rat brain after ischemia using a translocator protein (18 kDa) PET ligand [11C]DAC with ultra-high specific activity},
 volume = {54},
 year = {2011}
}