@article{oai:repo.qst.go.jp:00045969,
 author = {Mitsuhashi, Akira and Uno, Takashi and Usui, Akihiro and Tate, Shinichi and Hirashiki, Koichiro and Kato, Kazuyoshi and Kiyohara, Hiroki and Kato, Shingo and Ito, Hisao and Syozu, Makio and 三橋 暁 and 宇野 隆 and 清原 浩樹 and 加藤 眞吾 and 伊東 久夫 and 生水 真紀夫},
 issue = {6},
 journal = {Anticancer Research},
 month = {Jun},
 note = {Aim: To determine the effectiveness of postoperative concurrent daily low-dose cisplatin-based chemoradiation (CCRT) in patients with high-risk cervical cancer. Patients and Methods: Patients with stage IB, IIA, or IIB cervical cancer who were initially treated with radical hysterectomy and pelvic lymphadenectomy, and were proven to have pelvic lymph node metastasis (pN1) or microscopic involvement of the parametrium (pT2b), participated in this study. Thirty-one patients received adjuvant CCRT with daily low-dose (6-8.5 mg/m2) cisplatin (daily CCRT group). A non-randomised control group of 44 patients received adjuvant radiotherapy alone (RT group). Results: Overall survival (OS) at 4 years was 61% in the RT group and 91% in the daily CCRT group (p=0.004). Hazard ratio for poorer recurrence-free survival (RFS) in the RT group vs. the CCRT group was 7.9 (p=0.006). In the daily CCRT group, daily cisplatin chemotherapy was successfully completed in 27 out of 31 patients, although toxicity of grade ≥3 was found in 29% for neutropenia and 17% for gastrointestinal tract toxicity. Conclusion: Postoperative adjuvant CCRT with daily low-dose cisplatin improved RFS and OS of pT2b or pN1 patients, with acceptable compliance.},
 pages = {2341--2346},
 title = {Postoperative Concurrent Daily Low-dose Cisplatin-based Chemoradiation Improves the Prognosis of Patients with Pathologic T2b or N1 Cervical Cancer},
 volume = {30},
 year = {2010}
}