@article{oai:repo.qst.go.jp:00045950,
 author = {Kono, Kenji and Nakashima, Seiji and Kokuryo, Daisuke and Aoki, Ichio and et.al and 國領 大介 and 青木 伊知男},
 issue = {5},
 journal = {Biomaterials},
 month = {Nov},
 note = {For development of tumor-specific chemotherapy, we designed liposomes with temperature-triggered drug release and magnetic resonance imaging (MRI) functions. We prepared multi-functional liposomes by incorporating thermosensitive poly(2-ethoxy(ethoxyethyl)vinyl ether) chains with a lower critical solution temperatures around 40 C and polyamidoamine G3 dendron-based lipids having Gd3+ chelate residues into pegylated liposomes. These stable doxorubicin (DOX)-loaded liposomes retained DOX in their interior below physiological temperature but released DOX immediately at temperatures greater than 40 C. They exhibited excellent ability to shorten the longitudinal proton relaxation time. When administered intravenously into colon 26 tumor-bearing mice, accumulated liposomes in tumors increased with time, reaching a constant level 8 h after administration by following T1-weighted MRI signal intensity in tumors. Liposome size affected the liposome accumulation efficiency in tumors: liposomes of about 100 nm diameter were accumulated more efficiently than those with about 50 nm diameter. Tumor size also affected accumulation: more efficient accumulation occurred in larger tumors. Tumor growth was strongly suppressed when liposomes loaded with DOX were administered intravenously into tumor-bearing mice and the tumor was heated mildly at 44 C for 10 min at 8 h after administration. Multi-functional liposomes having temperature-triggered drug release and MRI functions might engender personalized chemotherapy, providing efficient patient-optimized chemotherapy.},
 pages = {1387--1395},
 title = {Multi-functional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy},
 volume = {32},
 year = {2010}
}