{"created":"2023-05-15T14:35:40.511001+00:00","id":45883,"links":{},"metadata":{"_buckets":{"deposit":"9ffd49d9-8986-4d14-a5cc-fae10ffdc96b"},"_deposit":{"created_by":1,"id":"45883","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45883"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045883","sets":["1"]},"author_link":["456385","456386","456378","456381","456384","456383","456389","456379","456382","456387","456380","456388"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"742","bibliographicPageStart":"734","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Oncology Biology Physics"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: To retrospectively analyze the results of intraoperative radiotherapy (IORT) with or without external beam radiotherapy (EBRT) for resected pancreatic cancer. METHODS AND MATERIALS: The records of 210 patients treated with gross complete resection (R0: 147 patients; R1: 63 patients) and IORT with or without EBRT were reviewed. One hundred forty-seven patients (70.0%) were treated without EBRT and 114 patients (54.3%) were treated in conjunction with chemotherapy. The median doses of IORT and EBRT were 25 Gy (range, 20-30 Gy) and 45 Gy (range, 20-60Gy), respectively. The median follow-up of the surviving 62 patients was 26.3 months (range, 2.7-90.5 months). RESULTS: At the time of this analysis, 150 of 210 patients (71.4%) had disease recurrences. Local failure was observed in 31 patients (14.8%), and the 2-year local control rate in all patients was 83.7%. The median survival time and the 2-year actuarial overall survival (OS) in all 210 patients were 19.1 months and 42.1%, respectively. Patients treated with IORT and chemotherapy had a significantly more favorable OS than those treated with IORT alone (p = 0.0011). On univariate analysis, chemotherapy use, degree of resection, carbohydrate antigen 19-9, and pathological N stage had a significant impact on OS and on multivariate analysis; these four factors were significant prognostic factors. Late gastrointestinal morbidity of NCI-CTC Grade 4 was observed in 7 patients (3.3%). CONCLUSION: IORT yields an excellent local control rate for resected pancreatic cancer with few frequencies of severe late toxicity, and IORT combined with chemotherapy confers a survival benefit compared with that of IORT alone. (c) 2010 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0360-3016","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ogawa, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"456378","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karasawa, Katsuyuki"}],"nameIdentifiers":[{"nameIdentifier":"456379","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Yoshinori"}],"nameIdentifiers":[{"nameIdentifier":"456380","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogawa, Yoshihiro"}],"nameIdentifiers":[{"nameIdentifier":"456381","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jingu, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"456382","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wada, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"456383","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takayama, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"456384","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nemoto, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"456385","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"456386","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小川 芳弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"456387","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神宮 啓一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"456388","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根本 建二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"456389","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Intraoperative radiotherapy for resected pancreatic cancer: a multi-institutional retrospective analysis of 210 patients.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intraoperative radiotherapy for resected pancreatic cancer: a multi-institutional retrospective analysis of 210 patients."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-25"},"publish_date":"2010-08-25","publish_status":"0","recid":"45883","relation_version_is_last":true,"title":["Intraoperative radiotherapy for resected pancreatic cancer: a multi-institutional retrospective analysis of 210 patients."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:58:27.139286+00:00"}