{"created":"2023-05-15T14:35:40.377678+00:00","id":45880,"links":{},"metadata":{"_buckets":{"deposit":"e3556683-509a-40d0-959a-94ef5e694946"},"_deposit":{"created_by":1,"id":"45880","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45880"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045880","sets":["1"]},"author_link":["456352","456353","456355","456356","456354"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"277","bibliographicPageStart":"272","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Radiation Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE: The aim of this study was to assess the radiosensitivities and homogeneous efficacy in the spread-out Bragg peak (SOBP) for lung cancer cell lines exposed to carbon ions. MATERIALS AND METHODS: The dose-dependent survival rates of seven cell lines exposed to carbon ions, fast neutrons, and photons were obtained using colony-forming assays in vitro. The relative biological effectiveness (RBE) of carbon ions and fast neutrons to photons was determined by comparing the doses at the 10% and 1% survival levels. RESULTS: The RBEs at 13, 40, 50, and 80 keV/microm were 1.20-1.29, 1.55-1.80, 1.57-2.00, and 1.69-2.58, respectively, at the 10% survival level. The RBE of 290 MeV carbon ions increased with increasing linear energy transfer. The biological dose (relative physical dose x RBE) distributions in the SOBP did not statistically differ at the proximal, mid, or distal points at the 10% (p = 0.945) and 1% (p = 0.211) survival levels, respectively; however, deviation of the biological dose at 10% and 1% survival were 3%-16% and 6%-24%, respectively. Furthermore, 290 MeV carbon ions at 80 keV/microm in the SOBP were nearly equivalent to 30 MeV fast neutrons. CONCLUSION: Our results demonstrate nearly homogeneous effectiveness in the SOBP, although we are aware of the deviation in some cell lines","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s11604-007-0134-6","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-2043","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Takiguchi, Yasuo"}],"nameIdentifiers":[{"nameIdentifier":"456352","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyamoto, Tadaaki"}],"nameIdentifiers":[{"nameIdentifier":"456353","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagao, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"456354","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuriyama, Takayuki"}],"nameIdentifiers":[{"nameIdentifier":"456355","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本 忠昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"456356","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Assessment of the homogeneous efficacy of carbon ions in the spread-out Bragg peak for human lung cancer cell lines","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Assessment of the homogeneous efficacy of carbon ions in the spread-out Bragg peak for human lung cancer cell lines"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-13"},"publish_date":"2010-08-13","publish_status":"0","recid":"45880","relation_version_is_last":true,"title":["Assessment of the homogeneous efficacy of carbon ions in the spread-out Bragg peak for human lung cancer cell lines"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:58:29.326700+00:00"}