@article{oai:repo.qst.go.jp:00045872,
 author = {Takano, Akihiro and Arakawa, Ryosuke and Ito, Hiroshi and Tateno, Amane and Takahashi, Hidehiko and Matsumoto, Ryohei and Okubo, Yoshiro and Suhara, Tetsuya and 高野 晶寛 and 荒川 亮介 and 伊藤 浩 and 舘野 周 and 高橋 英彦 and 松本 良平 and 大久保 善朗 and 須原 哲也},
 issue = {7},
 journal = {The International Journal of Neuropsychopharmacology},
 month = {Aug},
 note = {Inflammatory/immunological process and glial contribution are suggested in the pathophysiology of schizophrenia. We investigated peripheral benzodiazepine receptors in brains of patients with chronic schizophrenia, which were reported to be located on mitochondria of glial cells, using [11C]DAA1106 with positron emission tomography. Fourteen patients and 14 age- and sex-matched normal controls participated in this study. PET data were analysed by two-tissue compartment model with metabolite-corrected plasma input. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale. There was no significant difference between [11C]DAA1106 binding of the cortical regions of normal controls and patients with schizophrenia, whereas the patients showed a positive correlation between cortical [11C]DAA1106 binding and positive symptom scores. There was also a positive correlation between [11C]DAA1106 binding and duration of illness. Although the correlations need to be interpreted very cautiously, involvement of glial reaction process in the pathophysiology of positive symptoms or progressive change of schizophrenia might be suggested.},
 pages = {943--950},
 title = {Peripheral benzodiazepine receptors in patients with chronic schizophrenia: A PET study with [11C]DAA1106},
 volume = {13},
 year = {2010}
}