{"created":"2023-05-15T14:35:39.227162+00:00","id":45854,"links":{},"metadata":{"_buckets":{"deposit":"0619d7c6-8d84-4dd1-93af-4fa49ded894c"},"_deposit":{"created_by":1,"id":"45854","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45854"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045854","sets":["1"]},"author_link":["456049","456050","456052","456053","456058","456055","456051","456054","456057","456056"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"43","bibliographicPageStart":"35","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Oncology Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Whereas the Her2/neu/erbB2 receptor (Her2) could be a molecular target of the receptor-positive breast cancer, the therapeutic targets of Her2-negative cancer largely remain to be established. The expression of Her2 was evaluated in 48 primary breast cancer tumors by immunohistochemistry. The identified Notch pathway was studied in genotoxin-dependent suppression of breast cancer-initiating cell growth. Immunohistochemical assessment of Her2-negative tumors revealed significant association with overexpression of Notch1 and Notch3. Knockdown of Notch pathway resulted in sensitization of breast cancer cells to deionizing radiation, leading to cell death; the effect was more significant in stem marker CD44+ than in CD44- cells, and more profound in the Her2-negative than in positive cancer cells. The present study indicates that inhibition of Notch signaling could antagonize survival signal of Her2-negative breast cancer-initiating cells carrying genomic damage, and suggests that targeted suppression of the Notch pathway may give the rationale for sensitizing Her2-negative cancer-initiating cells to a therapeutic approach.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1021-335X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirose, Hajime"}],"nameIdentifiers":[{"nameIdentifier":"456049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Hideshi"}],"nameIdentifiers":[{"nameIdentifier":"456050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimori, Koshi"}],"nameIdentifiers":[{"nameIdentifier":"456051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"456052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sekimoto, Mitsugu"}],"nameIdentifiers":[{"nameIdentifier":"456053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Doki, Yuichiro"}],"nameIdentifiers":[{"nameIdentifier":"456054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"456055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"456056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 秀始","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"456057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤 俊行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"456058","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-12"},"publish_date":"2010-07-12","publish_status":"0","recid":"45854","relation_version_is_last":true,"title":["Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:58:49.596245+00:00"}