{"created":"2023-05-15T14:35:38.796323+00:00","id":45844,"links":{},"metadata":{"_buckets":{"deposit":"6d156faa-240a-4607-aed4-1abb8bd58499"},"_deposit":{"created_by":1,"id":"45844","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45844"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045844","sets":["1"]},"author_link":["856278","856289","856268","856272","856290","856288","856273","856287","856274","856277","856282","856285","856281","856280","856275","856283","856270","856279","856271","856286","856291","856269","856276","856284"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"388","bibliographicPageStart":"380","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Nuclear Medicine Communications"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background  Malignant mesothelioma is a highly\naggressive form of cancer. Curative surgery is the only\neffective therapy for mesothelioma, and therefore early diagnosis is important. \nHowever, early diagnosis is difficult using current diagnostic imaging techniques, and a new imaging method for early diagnosis is urgently required.\nWe evaluated the affinity of radiolabeled monoclonal antibodies to the C-terminal fragment of ERC/mesothelin for this purpose.\nMethods 111 In-labeled or125 I-labeled IgG against C-terminal fragment of ERC and its Fab fragment were evaluated in vitro by cell binding, competitive inhibition, and cellular internalization assays, and in vivo by biodistribution in mice bearing ERC-expressing tumors. Next, the Fab fragment was labeled with the positron emitte 64 Cu and evaluated by positron emission tomography (PET).\nResults  Radiolabeled IgG and Fab showed specific binding to ERC-expressing mesothelioma cells with high affinity. Both radiolabeled IgG and Fab internalized into\ncells after binding to ERC on the cell surface.\n111 In-labeled IgG accumulated in ERC-expressing tumors and resulted in a moderate tumor-to-blood ratio at 4 days after injection. Furthermore, PET using 64 Cu-labeled Fab visualized the tumor at 6 h after injection.\nConclusion64Cu-labeled Fab can be useful for ERC-specific PET imaging, and can thus facilitate improved diagnosis of patients with early-stage mesothelioma.  \nNucl Med Commun 00:000–000  c   2010 Wolters Kluwer Health |Lippincott Williams & Wilkins.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/mnm.0b013e328336733d","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0143-3636","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Chisato"}],"nameIdentifiers":[{"nameIdentifier":"856268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sogawa, Chizuru"}],"nameIdentifiers":[{"nameIdentifier":"856269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"856270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sudou, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"856271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyou, Aya"}],"nameIdentifiers":[{"nameIdentifier":"856272","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uehara, Tomoya"}],"nameIdentifiers":[{"nameIdentifier":"856273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hino, Okio"}],"nameIdentifiers":[{"nameIdentifier":"856274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshii, Yukie"}],"nameIdentifiers":[{"nameIdentifier":"856275","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujibayashi, Yasuhisa"}],"nameIdentifiers":[{"nameIdentifier":"856276","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu"}],"nameIdentifiers":[{"nameIdentifier":"856277","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koizumi, Mitsuru"}],"nameIdentifiers":[{"nameIdentifier":"856278","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arano, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"856279","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"856280","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Chisato","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856281","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sogawa, Chizuru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856282","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856283","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sudo, Hitomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856284","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyo, Aya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uehara, Tomoya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshii, Yukie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukumura, Toshimitsu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koizumi, Mitsuru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arano, Yasushi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"856291","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Development of Positron Emission Tomography Imaging by 64Cu-labeled Fab for Detecting ERC/mesothelin in a Mesothelioma Mouse Model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Development of Positron Emission Tomography Imaging by 64Cu-labeled Fab for Detecting ERC/mesothelin in a Mesothelioma Mouse Model"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-12-11"},"publish_date":"2009-12-11","publish_status":"0","recid":"45844","relation_version_is_last":true,"title":["Development of Positron Emission Tomography Imaging by 64Cu-labeled Fab for Detecting ERC/mesothelin in a Mesothelioma Mouse Model"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:18:15.138952+00:00"}