@article{oai:repo.qst.go.jp:00045841,
 author = {Saijo, Tomoyuki and Takano, Akihiro and Suhara, Tetsuya and Arakawa, Ryosuke and Okumura, Masaki and Ichimiya, Tetsuya and Ito, Hiroshi and Okubo, Yoshiro and 西條 朋行 and 高野 晶寛 and 須原 哲也 and 荒川 亮介 and 奥村 正紀 and 一宮 哲哉 and 伊藤 浩 and 大久保 善朗},
 issue = {6},
 journal = {The International Journal of Neuropsychopharmacology},
 month = {Jul},
 note = {In our previous positron emission tomography (PET) study, we demonstrated that ECT decreased dopamine D2 receptor in major depressive disorder (MDD). Although many animal studies have focused on the effect of ECT on serotonergic neurotransmission, no human study has directly examined the effect of ECT on brain serotonin [5-hydroxytryptamine (5-HT)] 1A receptors (5-HT1ARs). Using PET with [11C]WAY 100635, we aimed to evaluate the effect of ECT on 5-HT1ARs in patients with MDD. Nine patients underwent PET scans before and after a series of 6-7 bilateral ECTs. Region-of-interest analysis was performed based on the simplified reference tissue model. There were no significant changes in 5-HT1AR binding in patients between before and after ECT. ECT did not alter [11C]WAY 100635 binding even after recovery from depressive episode. Although the present finding does not exclude the involvement of brain 5-HT1A systems in the antidepressant action of ECT, it may indicate the involvement of other neurotransmission mechanisms.},
 pages = {785--791},
 title = {Effect of Electroconvulsive Therapy on 5-HT1A Receptor Binding in Patients with Depression: A PET study with [11C]WAY 10063},
 volume = {13},
 year = {2010}
}