@article{oai:repo.qst.go.jp:00045827,
 author = {Hirano, Shigeki and Shimada, Hitoshi and Shinoto, Hitoshi and Hattori, Takamichi and et.al and 平野 成樹 and 島田 斉 and 篠遠 仁},
 issue = {9},
 journal = {Journal of Neurology, Neurosurgery, and Psychiatry},
 month = {Sep},
 note = {BACKGROUND: Pure autonomic failure (PAF) is a selective peripheral disorder in which Lewy bodies form within the autonomic ganglia. Patients with this disorder usually have no central lesions; however, chronic autonomic failure may secondarily affect the central nervous system. This study evaluated brain perfusion in patients with PAF by using N-isopropyl-p-(123)I iodoamphetamine ((123)I-IMP) single photon emission computed tomography (SPECT). METHODS: Six patients with PAF (all men; mean (SD) age 68+/-5 years) who had experienced autonomic symptoms for more than 5 years and six age-matched healthy control subjects (all men; mean (SD) age 67+/-5 years) were included in this study. The regions of interest (ROI) on spacially normalized (123)I-IMP SPECT images were automatically computed for both groups. RESULTS: Perfusion of the dorsal anterior cingulate cortex was decreased in the PAF group compared with the healthy control group (0.93 vs 1.01; p<0.001). In the other brain regions measured, there was no significant difference in regional perfusion between the two groups. CONCLUSIONS: The dorsal anterior cingulate cortex is poorly perfused and may be functionally altered in patients with PAF. The reduced perfusion in such individuals may be a secondary change that results from chronic autonomic failure.},
 pages = {1053--1055},
 title = {Reduced perfusion in the anterior cingulate cortex of patients with pure autonomic failure: an 123 I-IMP SPECT study},
 volume = {80},
 year = {2009}
}