@article{oai:repo.qst.go.jp:00045790,
 author = {Tanimoto, Katsuyuki and Yoshikawa, Kyosan and Obata, Takayuki and Ikehira, Hiroo and Shiraishi, Takahiro and Watanabe, Kazuhiro and Saga, Tsuneo and Mizoe, Junetsu and Kamada, Tadashi and Miyazaki, Masaru and et.al and 谷本 克之 and 吉川 京燦 and 小畠 隆行 and 池平 博夫 and 白石 貴博 and 渡邊 和洋 and 佐賀 恒夫 and 溝江 純悦 and 鎌田 正 and 宮崎 勝},
 issue = {6},
 journal = {Nuclear Medicine Communications},
 month = {Jun},
 note = {OBJECTIVE: Standardized uptake value (SUV) is affected by many factors. In that respect, the brain reference index (BRI: regions of interest of tumor/regions of interest of cerebellum) is one of the quantitative approaches to eliminate the variety of factors that affect SUV. MRI pulse sequence findings can also provide information about tissue cellularity. This information is useful for evaluating the malignancy of lesions. We evaluated the role of glucose metabolism and cellularity for the diagnosis of pancreatic tumor malignancy. METHOD: We performed a radionuclide 2-(18)F-fluoro-2-deoxyglucose ((18)F-FDG) uptake analysis and a signal intensity analysis using MRI on 16 presurgery patients with either proven or suspected pancreatic cancer. The tumor glucose metabolism was evaluated with SUV and BRI in an FDG-PET study. Tumor cellularity was determined with the MRI factors, apparent diffusion coefficient (ADC), T2 value and tumor to nontumor ratio of proton density. We compared these results with the pathological findings. RESULTS: SUV (= 0.855), BRI ( =0.875), and ADC ( =0.830) showed a larger the area under the curve than T2 value (= 0.582) and tumor to nontumor ratio of proton density ( = 0.786) according to the receiver operating characteristics analysis, and we therefore considered that these three factors were better indexes for the diagnosis of tumor malignancy. SUV and BRI had a high specificity. In contrast, ADC had a high sensitivity. CONCLUSION: The glucose metabolism with PET/CT and cellularity with MRI are different indexes for the diagnosis of tumor malignancy. Both provide necessary information for making an accurate diagnosis. Using both types of information may therefore help in obtaining a highly accurate diagnosis.},
 pages = {604--609},
 title = {Role of glucose metabolism and cellularity for tumor malignancy evaluation using FDG-PET/CT and MRI},
 volume = {31},
 year = {2010}
}