{"created":"2023-05-15T14:35:35.592385+00:00","id":45770,"links":{},"metadata":{"_buckets":{"deposit":"0f5b151e-f6b9-45df-8b67-b564fe71a97b"},"_deposit":{"created_by":1,"id":"45770","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45770"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045770","sets":["1"]},"author_link":["455006","455008","455001","455009","455004","455003","455000","455007","455005","455002","454999"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"378","bibliographicPageStart":"370","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Biological & Pharmaceutical Bulletin"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Multivalent interactions are frequently used to enhance ligand-receptor binding affinity. In this study,\nmono-, di- and trimeric Ala-Val-Thr-Gly-Arg-Gly-Asp-Ser-Tyr (AVTGRGDSY) peptides, labeled with 125I or\nCy5.5, were compared in vitro and in vivo. Using human embryonic kidney HEK293 (naturally aV-positive and\nb 3-negative), HEK293(b 1) (b 1-transfected and aVb 3-negative), HEK293(b 3) (b 3-transfected and strongly aVb 3-\npositive), and human glioblastoma U87MG (naturally aVb 3-positive) cell lines we evaluated their binding affinity\nand specificity. In vitro, the monomeric AVTGRGDSY showed specific binding to both HEK293(b 1) and\nHEK293(b 3) cells. Multimerization resulted in no change toward HEK293 cells, diminished binding with\nHEK293(b 1) cells, but substantially enhanced binding with aVb 3-positive HEK293(b 3) and U87MG cells. Moreover,\nmultimeric AVTGRGDSY peptides were found to be nearly comparable to the same molar concentration of\na well-known aVb 3-specific cyclo(RGDfV) (c(RGDfV)) peptide in specificity and affinity for targeting aVb 3 integrin.\nNon-invasive in vivo optical imaging demonstrated that as compared to its monomeric analogue, the Cy5.5-\nlabeled dimeric AVTGRGDSY peptide produced markedly enhanced tumor-to-background contrast in\nHEK293(b 3) tumor-bearing mice than in HEK293(b 1) tumor-bearing mice. In conclusion, the present study\nshowed the difference of monomeric and multimeric linear Arg-Gly-Asp (RGD)-containing compound in integrin\nselectivity and affinity. Our data provide useful information for the design of novel RGD peptides.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.33.370","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jin, Zhao-Hui"}],"nameIdentifiers":[{"nameIdentifier":"454999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furukawa, Takako"}],"nameIdentifiers":[{"nameIdentifier":"455000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Waki, Atsuo"}],"nameIdentifiers":[{"nameIdentifier":"455001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Coll, Jean-Luc"}],"nameIdentifiers":[{"nameIdentifier":"455002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"455003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujibayashi, Yasuhisa"}],"nameIdentifiers":[{"nameIdentifier":"455004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"455005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金 朝暉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古川 高子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤林 康久","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"455009","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Multimerization of a Linear Arg-Gly-Asp Peptide on Integrin Binding Affinity and Specificity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Multimerization of a Linear Arg-Gly-Asp Peptide on Integrin Binding Affinity and Specificity"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-24"},"publish_date":"2010-03-24","publish_status":"0","recid":"45770","relation_version_is_last":true,"title":["Effect of Multimerization of a Linear Arg-Gly-Asp Peptide on Integrin Binding Affinity and Specificity"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:59:48.322973+00:00"}