{"created":"2023-05-15T14:35:35.548426+00:00","id":45769,"links":{},"metadata":{"_buckets":{"deposit":"0f3107a8-6c3d-44f7-8f97-4dcc430b71be"},"_deposit":{"created_by":1,"id":"45769","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45769"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045769","sets":["1"]},"author_link":["454996","454989","454998","454992","454987","454995","454983","454986","454991","454994","454990","454988","454993","454984","454997","454985"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"87","bibliographicPageStart":"83","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Annals of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To investigate the effects of the clinical dose of clarithromycin, a substrate of P-glycoprotein (P-gp), on P-gp function using positron emission tomography (PET) with [(11)C]verapamil. METHODS: Two PET scanning with [(11)C]verapamil were performed before and after administration of 400 mg/day of clarithromycin on each of four healthy male subjects. The rate constant of transfer from plasma to brain (K (1)) was estimated by integration plot method. RESULTS: K (1) values of [(11)C]verapamil before administration of clarithromycin were 0.042-0.070 mL/cm(3)/min (0.054 +/- 0.012) and those after administration were 0.037-0.066 mL/cm(3)/min (0.055 +/- 0.013). No significant change in K (1) values of [(11)C]verapamil was observed between before and after administration of clarithromycin (P = 0.85). CONCLUSION: K (1) values of [(11)C]verapamil were not changed by clinical dose administration of clarithromycin, suggesting that a clinical dose of clarithromycin does not affect P-gp function at the blood-brain barrier.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-7187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Arakawa, Ryosuke"}],"nameIdentifiers":[{"nameIdentifier":"454983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"454984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"454985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morimoto, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"454986","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"454987","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hidehiko"}],"nameIdentifiers":[{"nameIdentifier":"454988","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takano, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"454989","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suhara, Tetsuya"}],"nameIdentifiers":[{"nameIdentifier":"454990","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454991","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454992","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"奥村 正紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454993","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森本 卓哉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晶寛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"454998","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-19"},"publish_date":"2010-03-19","publish_status":"0","recid":"45769","relation_version_is_last":true,"title":["No inhibitory effect on P-glycoprotein function at blood-brain barrier by clinical dose of clarithromycin: a human PET study with [11C]verapamil"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:59:49.023938+00:00"}