@article{oai:repo.qst.go.jp:00045726,
 author = {Zakeri, Farideh and Hirobe, Tomohisa and 廣部 知久},
 issue = {1},
 journal = {European Journal of Radiology},
 month = {Jan},
 note = {The aim of the present study was to assess occupationally induced chromosomal damage in hospital workers exposed to low levels of ionizing radiation. Thirty two interventional cardiologists, 33 conventional radiologists and 36 nuclear medicine physicians were included in this study, along with 35 healthy age- and sex-matched individuals as the control group. We used conventional metaphase chromosome aberration (CA) analysis, cytokinesis-block micronucleous (MN) assay and sister chromatid exchange (SCE) as important biological indicators of ionizing radiation exposure. Occupational dosimetry records were collected over the last year (ranged from 0.25 to 48 mSv) and their whole life exposure (ranged from 1.5 to 147 mSv). The results showed significantly higher frequencies of dicentric and acentric CAs (p < 0.001) and MN (p < 0.01) in all exposed groups than in the controls. SCEs and high frequency SCEs (HFC) were significantly higher in the cardiologists and nuclear medicine physicians (p < 0.05) than in the controls, but not in radiologists. Taking all the confounding factors into account, no obvious trend of increased chromosomal damages as a function of either duration of employment, exposed dose, sex or age was observed. Interventional cardiologists had the highest rates of CA and MN frequencies and nuclear medicine physicians had the highest rate of SCE and HFC frequencies between the worker groups, though the differences were not significant. These results indicate that long term exposure to low-dose ionizing radiation could result in DNA damage and mutagenicity. Hence, the personnel who work in the hospitals should carefully apply the radiation protection procedures.},
 pages = {191--195},
 title = {A cytogenetic approach to the effects of low levels of ionizing radiations on occupationally exposed individuals},
 volume = {73},
 year = {2010}
}