@article{oai:repo.qst.go.jp:00045687,
 author = {Serizawa, Itsuko and Kagei, Kenji and Kamada, Tadashi and Imai, Reiko and Sugahara, Shinji and Okada, Tohru and Tsuji, Hiroshi and Ito, Hisao and Tsujii, Hirohiko and 芹澤 慈子 and 影井 兼司 and 鎌田 正 and 今井 礼子 and 菅原 信二 and 岡田 徹 and 辻 比呂志 and 伊東 久夫 and 辻井 博彦},
 issue = {4},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Nov},
 note = {PURPOSE: To evaluate the applicability of carbon ion radiotherapy (CIRT) for unresectable retroperitoneal sarcomas with regard to normal tissue morbidity and local tumor control. METHODS AND MATERIALS: From May 1997 to February 2006, 24 patients (17 male and 7 female) with unresectable retroperitoneal sarcoma received CIRT. Age ranged from 16 to 77 years (median, 48.6 years). Of the patients, 16 had primary disease and 8 recurrent disease. Histologic diagnoses were as follows: malignant fibrous histiocytoma in 6, liposarcoma in 3, malignant peripheral nerve sheath tumor in 3, Ewing/primitive neuroectodermal tumor (PNET) in 2, and miscellaneous in 10 patients. The histologic grades were as follows: Grade 3 in 15, Grade 2-3 in 2, Grade 2 in 3, and unknown in 4. Clinical target volumes ranged between 57 cm(3) and 1,194 cm(3) (median 525 cm(3)). The delivered carbon ion dose ranged from 52.8 to 73.6 GyE in 16 fixed fractions over 4 weeks. RESULTS: The median follow-up was 36 months (range, 6-143 months). The overall survival rates at 2 and 5 years were 75% and 50%, respectively. The local control rates at 2 and 5 years were 77% and 69%. No complications of the gastrointestinal tract were encountered. No other toxicity greater than Grade 2 was observed. CONCLUSIONS: Use of CIRT is suggested to be effective and safe for retroperitoneal sarcomas. The results obtained with CIRT were a good overall survival rate and local control, notwithstanding the fact that most patients were not eligible for surgical resection and had high-grade sarcomas.},
 pages = {1105--10},
 title = {Carbon ion radiotherapy for unresectable retroperitoneal sarcomas},
 volume = {75},
 year = {2009}
}