@article{oai:repo.qst.go.jp:00045670,
 author = {Arakawa, Ryosuke and Ichimiya, Tetsuya and Ito, Hiroshi and Takano, Akihiro and Okumura, Masaki and Takahashi, Hidehiko and Takano, Harumasa and Yasuno, Fumihiko and Kato, Motoichiro and Okubo, Yoshiro and Suhara, Tetsuya and 荒川 亮介 and 一宮 哲哉 and 伊藤 浩 and 高野 晶寛 and 奥村 正紀 and 高橋 英彦 and 高野 晴成 and 安野 史彦 and 加藤 元一郎 and 大久保 善朗 and 須原 哲也},
 issue = {15},
 journal = {Journal of Psychiatric Research},
 month = {Oct},
 note = {Previous in vivo imaging studies reported no difference in dopamine transporter (DAT) bindings in the striatum between control subjects and patients with schizophrenia. However, as the signals of radioligands with moderate affinity were insufficient for allowing the evaluation of small amounts of DAT, DAT binding in extrastriatal regions has not been determined. Positron emission tomography scanning using [11C]PE2I was performed on eight patients with schizophrenia and twelve normal control subjects. Binding potential (BPND) for DAT in the caudate, putamen, thalamus and substantia nigra was calculated, using the cerebellum as reference region. In patients with schizophrenia, clinical symptoms were evaluated by Positive and Negative Syndrome Scale (PANSS). BPND in the thalamus of patients with schizophrenia was significantly higher than in control subjects (P = 0.044). In patients with schizophrenia, there were significantly positive correlations between BPND in the thalamus and total (r = 0.75), positive (r = 0.78) and negative PANSS scores (r = 0.82). Altered DAT in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia.},
 pages = {1219--1223},
 title = {Increase in thalamic binding of [11C]PE2I in patients with schizophrenia: A positron emission tomography study of dopamine transporter},
 volume = {43},
 year = {2009}
}