@article{oai:repo.qst.go.jp:00045664,
 author = {Nakano, Takashi and Kato, Shingo and Cao, JianPing and Juying, Zhou and Raden, Susworo and Nana, Supriana and Satou, Shinichirou and Ohno, Tatsuya and Suto, Hisao and Nakamura, Yuzuru and Koo, Chul Cho and Fuad, Ismail and Joy, C Calaguas Miriam and H, De Los Reyes Rey and Chansilpa, Yaowalak and Thephamongkhol, Kullathorn and Nguyen, Ba Duc and To, Anh Dung and Tsujii, Hirohiko and 中野 隆史 and 加藤 眞吾 and 佐藤 眞一郎 and 大野 達也 and 須藤 久男 and 中村 譲 and 辻井 博彦},
 issue = {3},
 journal = {Radiotherapy and Oncology},
 month = {May},
 note = {Purpose
\nRadiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted.
\nMaterials and methods
\nEleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50 Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28 Gy/4 fractions for HDR-ICBT and 30-40 Gy/1-2 fractions for LDR-ICBT.
\nResults
\nHundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32 Gy in the HDR group and 26-52.7 Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group.
\nConclusions
\nAlthough there were several problems with treatment compliance and patients follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia. 
\nKeywords: Cervical cancer; Radiotherapy; Developing country; International clinical study; East and south-east Asia},
 pages = {314--319},
 title = {A Regional Cooperative Clinical Study of Radiotherapy for Cervical Cancer in East and South-East Asian Countries},
 volume = {84},
 year = {2007}
}