@article{oai:repo.qst.go.jp:00045662,
 author = {Tsuji, Atsushi and Sogawa, Chizuru and Sudou, Hitomi and Sugyou, Aya and Koizumi, Mitsuru and Saga, Tsuneo and et.al and 辻 厚至 and 曽川 千鶴 and 須藤 仁美 and 須尭 綾 and 小泉 満 and 佐賀 恒夫},
 issue = {5},
 journal = {Journal of Nuclear Medicine},
 month = {Apr},
 note = {Acute allograft rejection remains a major complication after liver transplantation. We report a semiquantitative imaging method of detecting acute allograft rejection with 18F-FDG PET. Methods: Syngeneic and allogeneic transplanted rats, with or without immunosuppressive treatment, were subjected to serial PET. Autoradiography of the liver was conducted in both the syngeneic and the allogeneic rats. Results: A significant increment of 18F-FDG accumulation in liver allografts was observed by
PET on day 2. The 18F-FDG signal was concentrated in the area where inflammatory cells around the vessels were detected by autoradiography. Allotransplanted rats treated with an immunosuppressive agent displayed a marked decrease in hepatic 18F-FDG uptake, compared with allotransplanted rats that were not treated. Conclusion: 18F-FDG PET may be a valid method for facilitating the development of protocols to diagnose graftrejection and to monitor the efficacy of immunosuppressive therapy.},
 pages = {827--830},
 title = {18F-FDG PET for Semiquantitative Evaluation of Acute Allograft Rejection and Immunosuppressive Therapy Efficacy in Rat Models of Liver Transplantation},
 volume = {50},
 year = {2009}
}