@article{oai:repo.qst.go.jp:00045631,
 author = {Tsuruoka, Chizuru and Suzuki, Masao and Furusawa, Yoshiya and Anzai, Kazunori and Okayasu, Ryuichi and 鶴岡 千鶴 and 鈴木 雅雄 and 古澤 佳也 and 安西 和紀 and 岡安 隆一},
 issue = {2},
 journal = {Biological Sciences in Space},
 month = {Jul},
 note = {We investigated the influence of mutation induction on the hypoxanthine guanine phosphoribosyltransferase (hprt) locus in normal human fibroblasts irradiated with X
rays or accelerated iron ions with LET ranging from 200 to 400 keV/miceometer. The relative biological effectiveness (RBE) of the mutation frequency per total number of surviving cells for iron ions with comparatively lower LET values (200 and 260 keV/miceometer) in this study was higher than 1, and the RBE for the 300 keV/miceometer, 350 keV/miceometer and 400 keV/miceometer ions was nearly 1. These results indicated that the mutation induction for iron ions decreased with increasing LET, and these of high-LET regions (over 300 keV/miceometer) and X rays were similar. The deletion spectrum of exons in hprt locus for X rays and 260 keV/miceometer-iron ions were analyzed using multiplex polymerase chain reaction (PCR). About 70% of mutant induced by iron ions showed deletion of the entire exons (total deletion), while mutant induced by X rays showed partial deletion, which one or more exons are missing, of about 70%. The results indicated that iron-ion induced mutants sustained severer damage than X-ray induced mutants even if the doseresponse curves for mutation induction were similar between X rays and iron ions.},
 pages = {55--60},
 title = {The influence of mutation induction in normal human fibroblasts irradiated with X rays and iron ions},
 volume = {23},
 year = {2009}
}