{"created":"2023-05-15T14:35:26.598193+00:00","id":45609,"links":{},"metadata":{"_buckets":{"deposit":"ebe7451b-3024-4eb2-bcab-28b43650eccb"},"_deposit":{"created_by":1,"id":"45609","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45609"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045609","sets":["1"]},"author_link":["453209","453203","453208","453201","453212","453210","453207","453206","453199","453213","453214","453205","453202","453204","453211","453200"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1131","bibliographicPageStart":"1127","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"The International Journal of Neuropsychopharmacology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The acetylcholinesterase (AChE) inhibitor donepezil is also a sigma1 receptor agonist. We examined whether donepezil binds to sigma1 receptors in the living human brain after a single oral administration. Dynamic positron emission tomography (PET) data acquisition using the selective sigma1 receptor ligand [11C]SA4503 was performed to evaluate quantitatively the binding of [11C]SA4503 to sigma1 receptors in eight healthy male volunteers. Each subject had a PET scan before and after receiving a single dose of donepezil (5 or 10 mg). The binding potential of [11C]SA4503 was calculated. Doses of 5 mg and 10 mg donepezil bound to sigma1 receptors in the human brain with occupancies of ~60% and ~75%, respectively, in a dose-dependent manner. This study demonstrated that donepezil binds to sigma1 receptors in the living human brain at therapeutic doses. Therefore, sigma1 receptors may be implicated in the pharmacological mechanism of donepezil in the human brain.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1017/s1461145709990204","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1461-1457","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Masatomo"}],"nameIdentifiers":[{"nameIdentifier":"453199","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakata, Muneyuki"}],"nameIdentifiers":[{"nameIdentifier":"453200","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"453201","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"453202","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"453203","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyohara, Jun"}],"nameIdentifiers":[{"nameIdentifier":"453204","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wu, Jin"}],"nameIdentifiers":[{"nameIdentifier":"453205","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"453206","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iyo, Masaomi"}],"nameIdentifiers":[{"nameIdentifier":"453207","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hashimoto, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"453208","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"坂田 宗之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453209","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 賢二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453210","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453211","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"織田 圭一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453212","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石渡 喜一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453213","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本 謙二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"453214","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"High occupancy of sigma-1 receptors in the human brain after single oral administration of donepezil: A positron emission tomography study usig [11C]SA4503","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"High occupancy of sigma-1 receptors in the human brain after single oral administration of donepezil: A positron emission tomography study usig [11C]SA4503"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-08-18"},"publish_date":"2009-08-18","publish_status":"0","recid":"45609","relation_version_is_last":true,"title":["High occupancy of sigma-1 receptors in the human brain after single oral administration of donepezil: A positron emission tomography study usig [11C]SA4503"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:01:42.709620+00:00"}