@article{oai:repo.qst.go.jp:00045603,
 author = {Imaoka, Tatsuhiko and Nishimura, Mayumi and Iizuka, Daisuke and Daino, Kazuhiro and Takabatake, Takashi and Okamoto, Mieko and Kakinuma, Shizuko and Shimada, Yoshiya and 今岡 達彦 and 西村 まゆみ and 飯塚 大輔 and 臺野 和広 and 高畠 貴志 and 岡本 美恵子 and 柿沼 志津子 and 島田 義也},
 issue = {4},
 journal = {Journal of Radiation Research},
 month = {Jul},
 note = {Ionizing radiation is one of a few well-characterized etiologic factors of human breast cancer. Laboratory rodents serve as useful experimental models for investigating dose responses and mechanisms of cancer development. Using these models, a lot of information has been accumulated about mammary gland cancer, which can be induced by both chemical carcinogens and radiation. In this review, we first list some experimental rodent models of breast cancer induction. We then focus on several topics that are important in understanding the mechanisms and risk modification of breast cancer development, and compare radiation and chemical carcinogenesis models. We will focus on the pathology and natural history of cancer development in these models, genetic changes observed in induced cancers, indirect effects of carcinogens, and finally risk modification by reproductive factors and age at exposure to the carcinogens. In addition, we summarize the knowledge available on mammary stem/progenitor cells as a potential target of carcinogens. Comparison of chemical and radiation carcinogenesis models on these topics indicates certain similarities, but it also indicates clear differences in several important aspects, such as genetic alterations of induced cancers and modification of susceptibility by age and reproductive factors. Identification of the target cell type and relevant translational research for human risk management may be among the important issues that are addressed by radiation carcinogenesis models.},
 pages = {281--293},
 title = {Radiation-Induced Mammary Carcinogenesis in Rodent Models: What's Different from Chemical Carcinogenesis?},
 volume = {50},
 year = {2009}
}