@article{oai:repo.qst.go.jp:00045534,
 author = {Nozaki, Syoko and Kato, Motoichiro and Takano, Harumasa and Ito, Hiroshi and Takahashi, Hidehiko and Arakawa, Ryosuke and Okumura, Masaki and Fujimura, Yota and Matsumoto, Ryohei and Ota, Miho and Takano, Akihiro and Yasuno, Fumihiko and Okubo, Yoshiro and Suhara, Tetsuya and et.al and 野崎 昭子 and 加藤 元一郎 and 高野 晴成 and 伊藤 浩 and 高橋 英彦 and 荒川 亮介 and 奥村 正紀 and 藤村 洋太 and 松本 良平 and 太田 深秀 and 高野 晶寛 and 安野 史彦 and 大久保 善朗 and 須原 哲也},
 issue = {1/3},
 journal = {Schizophrenia Research},
 month = {Dec},
 note = {The dopamine hypothesis has been the most widely known theory concerning schizophrenia. However, the exact mechanism including presynaptic dopaminergic activity and its relationship with symptom severity still remains to be revealed. We measured presynaptic dopamine synthesis using positron emission tomography (PET) with L-[beta-11C]DOPA in 18 patients with schizophrenia (14 drug-naïve and 4 drug-free patients) and 20 control participants. Dopamine synthesis rates, expressed as ki values, were obtained using a graphical method, and the occipital cortex was used as reference region. Regions of interest were placed on the prefrontal cortex, temporal cortex, anterior cingulate, parahippocampus, thalamus, caudate nucleus, and putamen. Psychopathology was assessed with the Positive and Negative Symptom Scale (PANSS). We found significantly higher ki values in patients than in controls in the left caudate nucleus, but not in the other regions. The ki values in the thalamus exhibited a significant positive correlation with the PANSS total scores. Furthermore, a significant positive correlation was observed between the PANSS positive subscale scores and ki values in the right temporal cortex. Patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia.},
 pages = {78--84},
 title = {Regional Dopamine Synthesis in Patients with Schizophrenia using L-[beta -11C]DOPA PET},
 volume = {108},
 year = {2008}
}