@article{oai:repo.qst.go.jp:00045455,
 author = {Masamoto, Kazuto and Vazquez, Alberto and Wang, Ping and Kim, Seong-Gi and 正本 和人},
 journal = {Oxygen Transport to Tissue XXX (Advances in Experimental Medicine and Biology ; 645)},
 month = {Dec},
 note = {The dinamic changes in cerebral metabolic rata of oxygen (CMRO2) and oxygen supply suring brain functions have not been well-characterized. To examine this issue, experiments with electrophysiology, owygen microelectrode and laser-Doppler flowmetry were performed in the anesthetized rat somatosensory cortex. During neural activation, brain tissue partial pressure of oxygen(Po2) and local cerebral blood flow (CBF) were similarly increased. To separate the Po2 changes originating from the increase in CMRO2 and the increase in oxygen supply, the same experiments were repeated under a vasodilator-induced hypotension condition in which evoked CBF change was minimal. In this condition, evoked Po2 monotonically decreased, indicatingan increase in CMRO2. Then, CMRO2 was determined at resing as well as activation periods using a dynamic oxygen exchange model. Our results indicated that the changes in CMRO2were linearly related with the summation of evoked field potentials and further showed that the oxygen supply in the normal condition was about 2.5 times larger than the demand. However, this oxygen overspply was not explainable by the change in CBF alone, but at least partly by the increase in oxygenation levels at pre-capillary arterioles (e.g., 82% to 90% O2 saturation level) when local neural acivity was evoked.},
 pages = {287--292},
 title = {Brain Tissue Oxygen Consumption and Supply Induced by Neural Activation: Determined under suppressed hemodynamic response conditions in the anesthetized rat cerebral cortex},
 year = {2008}
}