{"created":"2023-05-15T14:35:13.196556+00:00","id":45406,"links":{},"metadata":{"_buckets":{"deposit":"5c6e0525-f9f4-46dc-a78b-18fe524ce54a"},"_deposit":{"created_by":1,"id":"45406","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45406"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045406","sets":["1"]},"author_link":["451040","451036","451038","451039","451037"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"1195","bibliographicPageStart":"1183","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Leukemia Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Microsatellite instability (MSI) in haematopoietic malignancies has been controversial. Particularly in non-Hodgkin lymphoma, the data published to date lack unity. Using a unique fluorescent technique, we found MSI in eight (14%) tumours in a panel of 59 carefully selected non-Hodgkin lymphoma patients. Our fluorescent technique also reveals two qualitatively distinct modes of MSI, i.e. Type A and Type B. Based on our previous studies using DNA mismatch repair (MMR) gene-knock out animals, we have concluded that Type A MSI is a direct consequence of defective MMR. MSI observed in non-Hodgkin lymphomas was uniformly Type A, which implies that MMR deficiency occurs in this malignancy. Intriguingly, in non-Hodgkin lymphoma patients treated by CHOP/VEPA-based therapies, response to chemotherapy was significantly worse in those with microsatellite-unstable tumours (p = 0.027). As a consequence, the patient outcomes at 1 year after treatment were significantly less favourable in this population (p = 0.046), although the survival difference was not statistically confirmed in a longer term. These findings suggest that in some non-Hodgkin lymphomas MMR deficiency may lead to drug resistance in tumour cells and, consequently, to poor patient outcomes. In non-Hodgkin lymphoma, MSI may be a potential biomarker that predicts the tumour response against chemotherapy.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0145-2126","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyashita, Kaname"}],"nameIdentifiers":[{"nameIdentifier":"451036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Mitsuaki"}],"nameIdentifiers":[{"nameIdentifier":"451037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"451038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"451039","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 光明","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"451040","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Frequent microsatellite instability in non-Hodgkin lymphomas irresponsive to chemotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Frequent microsatellite instability in non-Hodgkin lymphomas irresponsive to chemotherapy"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-01-28"},"publish_date":"2009-01-28","publish_status":"0","recid":"45406","relation_version_is_last":true,"title":["Frequent microsatellite instability in non-Hodgkin lymphomas irresponsive to chemotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:04:06.318765+00:00"}