@article{oai:repo.qst.go.jp:00045405, author = {Ikeda, Mizuyo and Fukuda, Satoshi and Nakamura, Mariko and Yoshida, Hiroki and Yan, Xueming and Xie, Yuyuan and 池田 瑞代 and 福田 俊 and 中村 麻利子 and 吉田 浩樹}, issue = {4}, journal = {Japanese Journal of Health Physics}, month = {Dec}, note = {We examined the effects of a diuretic, isotonic saline, and chelating agent, catechol-3, 6-bis (methyleiminodiacetic acid) (CBMIDA), on the excretion and prevention of renal damage of depleted uranium (DU). Male Wistar rats (8 weeks old) divided into seven groups were preinjected intraperitoneally with 4 mg/kg DU and then the six groups were injected intraperitoneally with a diuretic, a diuretic plus isotonic saline, 480 mg/kg or 720 mg/kg CBMIDA alone, or 480 mg/kg or 720 mg/kg CBMIDA plus a diuretic and saline for three days, and the one group was as the control (no treatment). The rats were killed 6 days after DU injection. The results indicated that the diuretic alone and the diuretic with isotonic saline were not effective in removing uranium from the body and protecting the renal function, and also did not help to increase significantly the effects of CBMIDA.}, pages = {354--358}, title = {Effects of a Diuretic and Its Combination with Chelating Agent on the Removal of Depleted Uranium in Rats}, volume = {43}, year = {2008} }