@article{oai:repo.qst.go.jp:00045383,
 author = {Ohno, Tatsuya and Nakano, Takashi and Kato, Shingo and Koo, C Cho and Chansilpa, Yaowalak and Pattaranutaporn, Pittyapoom and Jay, C Calaguas Miriam and H, De Los Reyes Rey and Zhou, Beibei and Juying, Zhou and Raden, Susworo and Nana, Supriana and To, Anh Dung and Fuad, Ismail and Satou, Shinichirou and Suto, Hisao and Nakamura, Yuzuru and Tsujii, Hirohiko and 大野 達也 and 中野 隆史 and 加藤 眞吾 and 佐藤 眞一郎 and 須藤 久男 and 中村 譲 and 辻井 博彦},
 issue = {5},
 journal = {International Journal of Radiation Oncology Biology Physics},
 month = {Apr},
 note = {Purpose
\nTo evaluate the toxicity and efficacy of accelerated hyperfractionated radiotherapy (RT) for locally advanced cervical cancer.
Methods and Materials
\nA multi-institutional prospective single-arm study was conducted among eight Asian countries. Between 1999 and 2002, 120 patients (64 with Stage IIB and 56 with Stage IIIB) with squamous cell carcinoma of the cervix were treated with accelerated hyperfractionated RT. External beam RT consisted of 30 Gy to the whole pelvis, 1.5 Gy/fraction twice daily, followed by 20 Gy of pelvic RT with central shielding at a dose of 2-Gy fractions daily. A small bowel displacement device was used with the patient in the prone position. In addition to central shielding RT, intracavitary brachytherapy was started. Acute and late morbidities were graded according to the Radiation Therapy Oncology Group and Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria.
Results
\nThe median overall treatment time was 35 days. The median follow-up time for surviving patients was 4.7 years. The 5-year pelvic control and overall survival rate for all patients was 84% and 70%, respectively. The 5-year pelvic control and overall survival rate was 78% and 69% for tumors ≥6 cm in diameter, respectively. No treatment-related death occurred. Grade 3-4 late toxicities of the small intestine, large intestine, and bladder were observed in 1, 1, and 2 patients, respectively. The 5-year actuarial rate of Grade 3-4 late toxicity at any site was 5%.
Conclusion
\nThe results of our study have shown that accelerated hyperfractionated RT achieved sufficient pelvic control and survival without increasing severe toxicity. This treatment could be feasible in those Asian countries where chemoradiotherapy is not available.},
 pages = {1522--1529},
 title = {Accelerated Hyperfractionated Radiotherapy for Cervical Cancer: Multi-institutional Prospective Study of Forum for Nuclear Cooperation in Asia among Eight Asian Countries},
 volume = {70},
 year = {2008}
}