{"created":"2023-05-15T14:35:08.187612+00:00","id":45330,"links":{},"metadata":{"_buckets":{"deposit":"13fc07fc-d054-4342-86e4-062be0f98619"},"_deposit":{"created_by":1,"id":"45330","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45330"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045330","sets":["1"]},"author_link":["450338","450337","450336"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5885","bibliographicPageEnd":"120","bibliographicPageStart":"117","bibliographicVolumeNumber":"321","bibliographic_titles":[{"bibliographic_title":"Science"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"After fertilization, maternal proteins in oocytes are degraded and new proteins encoded by the zygotic genome are synthesized. We found that autophagy, a process for the degradation of cytoplasmic constituents in the lysosome, plays a critical role during this period. Autophagy was triggered by fertilization and up-regulated in early mouse embryos. Autophagy-defective oocytes derived from oocyte-specific Atg5 (autophagy-related 5) knockout mice failed to develop beyond the four- and eight-cell stages if they were fertilized by Atg5-null sperm, but could develop if they were fertilized by wild-type sperm. Protein synthesis rates were reduced in the autophagy-null embryos. Thus, autophagic degradation within early embryos is essential for preimplantation development in mammals.","subitem_description_type":"Abstract"}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://www.sciencemag.org/cgi/content/full/321/5885/117"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.sciencemag.org/cgi/content/full/321/5885/117","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0036-8075","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsukamoto, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"450336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"450337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塚本 智史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450338","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Autophagy is essential for preimplantation development of mouse embryos","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Autophagy is essential for preimplantation development of mouse embryos"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-01"},"publish_date":"2008-12-01","publish_status":"0","recid":"45330","relation_version_is_last":true,"title":["Autophagy is essential for preimplantation development of mouse embryos"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:04:59.442374+00:00"}