@article{oai:repo.qst.go.jp:00045330,
 author = {Tsukamoto, Satoshi and et.al and 塚本 智史},
 issue = {5885},
 journal = {Science},
 month = {Jul},
 note = {After fertilization, maternal proteins in oocytes are degraded and new proteins encoded by the zygotic genome are synthesized. We found that autophagy, a process for the degradation of cytoplasmic constituents in the lysosome, plays a critical role during this period. Autophagy was triggered by fertilization and up-regulated in early mouse embryos. Autophagy-defective oocytes derived from oocyte-specific Atg5 (autophagy-related 5) knockout mice failed to develop beyond the four- and eight-cell stages if they were fertilized by Atg5-null sperm, but could develop if they were fertilized by wild-type sperm. Protein synthesis rates were reduced in the autophagy-null embryos. Thus, autophagic degradation within early embryos is essential for preimplantation development in mammals.},
 pages = {117--120},
 title = {Autophagy is essential for preimplantation development of mouse embryos},
 volume = {321},
 year = {2008}
}