{"created":"2023-05-15T14:35:06.465493+00:00","id":45304,"links":{},"metadata":{"_buckets":{"deposit":"a11649b5-93b4-4764-898e-eca54fd04a40"},"_deposit":{"created_by":1,"id":"45304","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45304"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045304","sets":["1"]},"author_link":["450066","450065","450060","450072","450064","450062","450061","450068","450069","450070","450063","450071","450067"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2","bibliographicPageEnd":"145","bibliographicPageStart":"135","bibliographicVolumeNumber":"634","bibliographic_titles":[{"bibliographic_title":"Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The comet assay was performed to elucidate the linearity of calibration curves and detection limits for DNA damage in multiple\norgans of whole body X-irradiated mice, and rates of reduction in DNA damage by DNA repair during the irradiation period were\nestimated in the respective organs by comparing the rates of increase in DNA damage at different absorbed dose rates of X-rays.\nOf the assay parameters, tail length and the percentage DNA in the tail showed a higher sensitivity to DNA damage in most organs\nthan Olive tail moment. Data at the higher absorbed dose rates (2.22 or 1.44 Gy/min) showed good correlations between absorbed\ndoses and these two parameters, with correlation coefficients of more than 0.7 in many organs. However, this assay had difficulty\ndetecting DNA damage at the lower absorption dose rate (0.72 Gy/min). The estimated rates of increase in DNA damage and those\nof DNA repair during the irradiation period in the respective organs suggested differences in the radiosensitivity of nuclear DNA\nand DNA repair capacity among organs. Our results indicated that absorbed dose rates of 1.0–1.3 Gy/min or greater were needed to\ninduce detectable DNA damages by the comet assay in many organs.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1383-5718","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ueno, Shunji"}],"nameIdentifiers":[{"nameIdentifier":"450060","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kashimoto, Takashige"}],"nameIdentifiers":[{"nameIdentifier":"450061","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Susa, Nobuyuki"}],"nameIdentifiers":[{"nameIdentifier":"450062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ito, Nobuhiko"}],"nameIdentifiers":[{"nameIdentifier":"450063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda, Shino"}],"nameIdentifiers":[{"nameIdentifier":"450064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"450065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Yuf"}],"nameIdentifiers":[{"nameIdentifier":"450066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiyama, Masayasu"}],"nameIdentifiers":[{"nameIdentifier":"450067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"450068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野 俊治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 伸彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武田 志乃","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 義一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"450072","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Assessment of DNA damage in multiple organs of mice after whole body X-irradiation using the comet assay","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Assessment of DNA damage in multiple organs of mice after whole body X-irradiation using the comet assay"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-22"},"publish_date":"2008-10-22","publish_status":"0","recid":"45304","relation_version_is_last":true,"title":["Assessment of DNA damage in multiple organs of mice after whole body X-irradiation using the comet assay"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:05:18.665441+00:00"}