@article{oai:repo.qst.go.jp:00045304,
 author = {Ueno, Shunji and Kashimoto, Takashige and Susa, Nobuyuki and Ito, Nobuhiko and Takeda, Shino and Nishimura, Yoshikazu and Sasaki, Yuf and Sugiyama, Masayasu and et.al and 上野 俊治 and 伊藤 伸彦 and 武田 志乃 and 西村 義一},
 issue = {1/2},
 journal = {Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research},
 month = {Dec},
 note = {The comet assay was performed to elucidate the linearity of calibration curves and detection limits for DNA damage in multiple
organs of whole body X-irradiated mice, and rates of reduction in DNA damage by DNA repair during the irradiation period were
estimated in the respective organs by comparing the rates of increase in DNA damage at different absorbed dose rates of X-rays.
Of the assay parameters, tail length and the percentage DNA in the tail showed a higher sensitivity to DNA damage in most organs
than Olive tail moment. Data at the higher absorbed dose rates (2.22 or 1.44 Gy/min) showed good correlations between absorbed
doses and these two parameters, with correlation coefficients of more than 0.7 in many organs. However, this assay had difficulty
detecting DNA damage at the lower absorption dose rate (0.72 Gy/min). The estimated rates of increase in DNA damage and those
of DNA repair during the irradiation period in the respective organs suggested differences in the radiosensitivity of nuclear DNA
and DNA repair capacity among organs. Our results indicated that absorbed dose rates of 1.0–1.3 Gy/min or greater were needed to
induce detectable DNA damages by the comet assay in many organs.},
 pages = {135--145},
 title = {Assessment of DNA damage in multiple organs of mice after whole body X-irradiation using the comet assay},
 volume = {634},
 year = {2007}
}