{"created":"2023-05-15T14:35:05.079949+00:00","id":45283,"links":{},"metadata":{"_buckets":{"deposit":"d905a583-16bf-40fe-ace9-93fe41f57f0e"},"_deposit":{"created_by":1,"id":"45283","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45283"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045283","sets":["1"]},"author_link":["449846","449840","449841","449844","449843","449845","449842","449839"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"55","bibliographicPageStart":"52","bibliographicVolumeNumber":"376","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Histone H2AX rapidly undergoes phosphorylation at Ser139 (gamma-H2AX) in response to DNA double-strand breaks. Although ATM kinase and DNA-PK phosphorylate Ser139 of H2AX in culture cells, the regulatory mechanism of gamma-H2AX level remains unclear in vivo. Here, we detected the phosphorylation of H2AX and the elimination of gamma-H2AX in the mouse skin after X-irradiation. Furthermore, following X-irradiation, the level of gamma-H2AX also increased in mice lacking either ATM or DNA-PK. Although the elimination after Xirradiation was detected in the skin of these mutant mice, the elimination in DNA-PK-deficient mice was slower than that in C3H and ATM knockout mice, suggesting that a fraction of gamma-H2AX in the skin is eliminated in a DNA-PK-dependent manner. Although the DNA-PK-dependent elimination of gamma-H2AX was also detected in the liver, kidney, and spleen, the DNA-PK-dependent phosphorylation of H2AX was detected in the spleen only. These results suggest that the regulatory mechanism of gamma-H2AX level is tissue- specific.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Koike, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"449839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugasawa, Jun"}],"nameIdentifiers":[{"nameIdentifier":"449840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Mariko"}],"nameIdentifiers":[{"nameIdentifier":"449841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koike, Aki"}],"nameIdentifiers":[{"nameIdentifier":"449842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 学","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅澤 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 万里子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 亜紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449846","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-08"},"publish_date":"2008-10-08","publish_status":"0","recid":"45283","relation_version_is_last":true,"title":["Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:05:34.317398+00:00"}