{"created":"2023-05-15T14:35:03.630467+00:00","id":45265,"links":{},"metadata":{"_buckets":{"deposit":"283881c6-b0fb-44c1-9b1b-c493e74531f6"},"_deposit":{"created_by":1,"id":"45265","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45265"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045265","sets":["1"]},"author_link":["449656","449651","449652","449653","449655","449654"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"448","bibliographicPageStart":"440","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"脳神経外科ジャーナル = Japanese Journal of Neurosurgery"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的：頭蓋底・傍頸髄腫瘍および中枢神経系腫瘍に対する炭素イオン線第I/II相臨床試験の途中解析を報告する。\n方法：頭蓋底・傍頚髄腫瘍では、炭素イオン線単独で16回/4週、中枢神経系腫瘍では、びまん性星細胞腫に対し炭素イオン線単独で24回/6週、悪性グリオーマに対しX線および抗がん剤治療を併用し、炭素イオン線で8回/2週の線量増加を行った。\n治療効果：すべての臨床試験において、急性および遅発性有害事象の大半は軽微であり、予期せぬ重篤な副作用は出現していない。頭蓋底・傍頚髄腫瘍の線量別にみた5年局所制御率は、48GyEで75％、52.8GyEで67％、57.6GyEで78％、60.8GyEで88％である。びまん性星細胞腫の線量別にみた5年Progression-Free Survival(PFS)は、50.4GyEで11％、55.2GyEで80％である。悪性グリオーマに対するX線および抗がん剤併用炭素イオン線治療では、退形成性星細胞腫16例のPFSの中央値(median PFS: m−PFS)は18ヶ月、膠芽腫32例は７ヶ月であった。\n結論：線量増加に伴い治療成績が向上する傾向が示されている。この結果から、悪性グリオーマは2002年4月から炭素イオン線単独第I/II相試験が開始し、頭蓋底・傍頸髄腫瘍は2004年4月から先進医療へ移行している。","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-950X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 安都佐"}],"nameIdentifiers":[{"nameIdentifier":"449651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江, 純悦"}],"nameIdentifiers":[{"nameIdentifier":"449652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井, 博彦"}],"nameIdentifiers":[{"nameIdentifier":"449653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 安都佐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"溝江 純悦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"449656","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"重粒子線治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重粒子線治療"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-09-16"},"publish_date":"2008-09-16","publish_status":"0","recid":"45265","relation_version_is_last":true,"title":["重粒子線治療"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:05:47.109580+00:00"}