@article{oai:repo.qst.go.jp:00045263,
 author = {Arakawa, Ryosuke and Okumura, Masaki and Ito, Hiroshi and Seki, Chie and Takahashi, Hidehiko and Takano, Harumasa and Nakao, Ryuji and Suzuki, Kazutoshi and Okubo, Yoshiro and Halldin, Christer and Suhara, Tetsuya and 荒川 亮介 and 奥村 正紀 and 伊藤 浩 and 関 千江 and 高橋 英彦 and 高野 晴成 and 鈴木 和年 and 大久保 善朗 and ハルディン クリスタ and 須原 哲也},
 issue = {8},
 journal = {Journal of Nuclear Medicine},
 month = {Aug},
 note = {(S,S)-18F-FMeNER-D2 was recently developed as a radioligand for the measurement of norepinephrine transporter imaging with PET. In this study, a norepinephrine transporter was visualized in the human brain using this radioligand with PET and quantified by several methods. METHODS: PET scans were performed on 10 healthy men after intravenous injection of (S,S)-18F-FMeNER-D2. Binding potential relative to nondisplaceable binding (BP(ND)) was quantified by the indirect kinetic, simplified reference-tissue model (SRTM), multilinear reference-tissue model (MRTM), and ratio methods. The indirect kinetic method was used as the gold standard and was compared with the SRTM method with scan times of 240 and 180 min, the MRTM method with a scan time of 240 min, and the ratio method with a time integration interval of 120-180 min. The caudate was used as reference brain region. RESULTS: Regional radioactivity was highest in the thalamus and lowest in the caudate during PET scanning. BP(ND) values by the indirect kinetic method were 0.54 +/- 0.19 and 0.35 +/- 0.25 in the thalamus and locus coeruleus, respectively. BP(ND) values found by the SRTM, MRTM, and ratio methods agreed with the values demonstrated by the indirect kinetic method (r = 0.81-0.92). CONCLUSION: The regional distribution of (S,S)-18F-FMeNER-D2 in our study agreed with that demonstrated by previous PET and postmortem studies of norepinephrine transporter in the human brain. The ratio method with a time integration interval of 120-180 min will be useful for clinical research of psychiatric disorders for estimation of norepinephrine transporter occupancy by antidepressants without requiring arterial blood sampling and dynamic PET.},
 pages = {1270--1276},
 title = {Quantitative Analysis of Norepinephrine Transporter in the Human Brain Using PET with (S,S)-18F-FMeNER-D2},
 volume = {49},
 year = {2008}
}