@article{oai:repo.qst.go.jp:00045250,
 author = {Tsuruoka, Chizuru and Suzuki, Masao and Hande, Prakash and Furusawa, Yoshiya and Anzai, Kazunori and Okayasu, Ryuichi and 鶴岡 千鶴 and 鈴木 雅雄 and Ｈａｎｄｅ Ｐｒａｋａｓｈ and 古澤 佳也 and 安西 和紀 and 岡安 隆一},
 issue = {2},
 journal = {Radiation Research},
 month = {Aug},
 note = {We studied the LET and ion-species dependence on the induction of chromatin breaks measured immediately after irradiation as initially measured breaks and after 24h-postirradiation incubation as non- rejoined breaks, in normal human fibroblasts with different heavy ions, such as carbon, neon, silicon and iron, generated by Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Science (NIRS). Chromatin breaks were measured as an excess number of fragments of prematurely condensed chromosomes using a technique of premature chromosome condensation (PCC). The result showed that the number of excess fragments per cell per Gy for initially measured chromatin breaks was dependent on LET values in the LET ranges from 13.3 to 113.1 keV/maicrmeter, while it was not dependent on ion-species. On the other hand, the number of non-rejoined chromatin breaks detected after 24h-postirradiation incubation was clearly dependent on LETs and ion-species. These results showed that no statistical difference was observed in the cross section for initially measured breaks but statistical difference was observed in that for non-rejoined breaks among carbon, neon silicon and iron ions. This suggests that the LET dependent structure in biological effects is reflected in biological consequences of repair processes.},
 pages = {163--171},
 title = {The difference in LET and ion species dependence for induction of initially measured and non-rejoined chromatin breaks in normal human fibroblasts.},
 volume = {170},
 year = {2008}
}