{"created":"2023-05-15T14:34:56.246086+00:00","id":45153,"links":{},"metadata":{"_buckets":{"deposit":"fec670c9-6b12-4867-9812-0207cc2c5331"},"_deposit":{"created_by":1,"id":"45153","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"45153"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00045153","sets":["1"]},"author_link":["448411","448417","448421","448415","448418","448420","448412","448416","448413","448419","448414","448410","448422"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"687","bibliographicPageStart":"679","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"European Journal of Nuclear Medicine and Molecular Imaging"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose:  [7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX) is a positron-emitting adenosine A2A receptor (A2AR) antagonist for visualisation of A2AR distribution by positron emission tomography (PET). \nThe aims of this paper were to use a kinetic model to analyse the behaviour of [11C]TMSX in the brain and to examine the applicability of the Logan plot. We also\nstudied the applicability of a simplified Logan plot by omitting metabolite correction and arterial blood sampling.\nMethods:  The centrum semiovale was used as a reference region on the basis of a post-mortem study showing that it has a negligibly low density of A2ARs. Compartmental analysis was performed in five normal subjects. Parametric images of A2AR binding potential (BP) were also generated using a Logan plot with or without metabolite correction and with or without arterial blood sampling. To omit arterial blood sampling, we applied a method to extract the plasma-related information using independent component analysis (EPICA).\nResults:  The estimated K1/k2 was confirmed to be common in the centrum semiovale and main cortices. The threecompartment model was well fitted to the other regions\nusing the fixed value of K1/k2 estimated from the centrum semiovale. The estimated BPs using the Logan plot matched those derived from compartment analysis. Without\nthe metabolite correction, the estimate of BP underestimated the true value by 5%. The estimated BPs agreed regardless of arterial blood sampling.\nConclusion:  A three-compartment model with a reference region, the centrum semiovale, describes the kinetic behaviour of [11C]TMSX PET images. A2ARs in the\nhuman brain can be visualised as a BP image using [11C]TMSX PET without arterial blood sampling.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00259-006-0294-0","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1619-7070","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naganawa, Mika"}],"nameIdentifiers":[{"nameIdentifier":"448410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"448411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mishina, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"448412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chihara, Kunihiro"}],"nameIdentifiers":[{"nameIdentifier":"448413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oda, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"448414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Kenji"}],"nameIdentifiers":[{"nameIdentifier":"448415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Kiichi"}],"nameIdentifiers":[{"nameIdentifier":"448416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"448417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"織田 圭一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 賢二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石渡 喜一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"448422","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-05-08"},"publish_date":"2008-05-08","publish_status":"0","recid":"45153","relation_version_is_last":true,"title":["Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:07:03.342893+00:00"}